PDF(Pubmed)
Abstract：
Granulomatous inflammation (GI) diseases are a group of chronic inflammation disorders characterized by focal collections of multinucleated giant cells, epithelioid cells and macrophages, with or without necrosis. GI diseases are closely related to microbes, especially virulent intracellular bacterial infections are important factors in the progression of these diseases. They employ a range of strategies to survive the stresses imposed upon them and persist in host cells, becoming the initiator of the fighting. Microbe-host communication is essential to maintain functions of a healthy host, so defense capacity of hosts is another influence factor, which is thought to combine to determine the result of the fighting. With the development of gene research technology, many human genetic loci were identified to be involved in GI diseases susceptibility, providing more insights into and knowledge about GI diseases. The current review aims to provide an update on the most recent progress in the identification and characterization of bacteria in GI diseases in a variety of organ systems and clinical conditions, and examine the invasion and escape mechanisms of pathogens that have been demonstrated in previous studies, we also review the existing data on the predictive factors of the host, mainly on genetic findings. These strategies may improve our understanding of the mechanisms underlying GI diseases, and open new avenues for the study of the associated conditions in the future.
摘要：
肉芽肿性炎症（GI）疾病是一组慢性炎症疾病，其特征是多核巨细胞的局灶性集合，上皮样细胞和巨噬细胞，有或没有坏死。胃肠道疾病与微生物密切相关,特别是毒性的细胞内细菌感染是这些疾病进展的重要因素。他们采用一系列策略来在施加于他们身上的压力下存活下来，并在宿主细胞中持续存在，成为战斗的发起者。微生物-宿主通信对于维持健康宿主的功能至关重要，所以宿主的防御能力是另一个影响因素，这被认为是结合起来确定战斗的结果。随着基因研究技术的发展,许多人类遗传基因座被鉴定为与胃肠道疾病易感性有关，提供更多关于胃肠道疾病的见解和知识。当前的审查旨在提供有关在各种器官系统和临床条件下胃肠道疾病中细菌的鉴定和表征的最新进展的最新信息。并检查在以前的研究中已经证明的病原体的入侵和逃逸机制，我们还回顾了宿主预测因素的现有数据，主要是遗传发现。这些策略可以提高我们对胃肠道疾病潜在机制的理解。并为未来相关条件的研究开辟了新的途径。
