PDF(Pubmed)
Abstract：
For humans, maternal old age means the age of 35 or older at the time of childbirth. Maternal metabolism not only affects the cognitive function of the offspring, but also affects their physical and neurological development. This study aims to elucidate the effects of exercise training on spatial learning memory, neurogenesis, and apoptosis in the off-spring of old mice. Using mice, the offspring of old mothers showed impaired spatial learning memory, decreased brain-derived neurotrophic factor and postsynaptic density protein 95 levels, suppressed neurogenesis, and increased hippocampal apoptotic cell death. In contrast, the offspring of the old mothers had improved spatial learning memory, increased brain-derived neurotrophic factor and postsynaptic density protein 95 levels, increased neurogenesis, and decreased hippocampal apoptotic cell death when they received exercise training. The present results indicate that there is apparent spatial learning memory impairment among the offspring of old mothers, but by contrast, exercise can ameliorate spatial learning memory impairment. Exercise can be an effective countermeasure against memory decline in the offspring of old mothers.
摘要：
对于人类来说,产妇高龄是指分娩时年龄在35岁或以上。母体代谢不仅影响后代的认知功能,还会影响他们的身体和神经发育。本研究旨在阐明运动训练对空间学习记忆的影响,神经发生，和老鼠后代的细胞凋亡。用老鼠，老年母亲的后代表现出受损的空间学习记忆，脑源性神经营养因子和突触后密度蛋白95水平降低，抑制神经发生，海马凋亡细胞死亡增加。相比之下,老母亲的后代改善了空间学习记忆，脑源性神经营养因子和突触后密度蛋白95水平升高，增加神经发生，当他们接受运动训练时，海马凋亡细胞死亡减少。目前的结果表明，老年母亲的后代之间存在明显的空间学习记忆障碍，但相比之下,运动可以改善空间学习记忆障碍。运动可以成为防止老年母亲后代记忆力下降的有效对策。
