PDF(Pubmed)
Abstract：
UNASSIGNED: To evaluate the clinicopathologic characteristics of head and neck solitary fibrous tumors and features that may predict tumor recurrence.
UNASSIGNED: Retrospective review.
UNASSIGNED: University of California-Los Angeles Medical Center.
UNASSIGNED: A single-center retrospective study was conducted on pathologically confirmed cases of head and neck solitary fibrous tumors between 1996 and 2021. Patient demographics, clinical course, and histopathologic features were evaluated. Recurrence-free survival was estimated via Kaplan-Meier analysis.
UNASSIGNED: A total of 52 patients were reviewed. The average patient age was 54.7 years (range, 15-89). The most common subsite was the orbit (53.8%, n = 28), but other involved areas included the nasopharynx, paranasal sinuses, and scalp. The median tumor size was 2.95 cm (range, 1.3-11.2). Strong STAT6 (100%) and CD34 (97.9%) expression was observed on immunohistochemistry. Almost all patients were initially managed with wide local excision; 82% of patients (n = 14) had positive margins on pathologic review; and 15% (n = 4) had recurrence at a median 28.5 months (range, 10-113). White patient race was the only significant predictor of tumor recurrence. Patient age (≥55 years), tumor size (≥4), high mitotic rate, and disease subsite were not associated with recurrence.
UNASSIGNED: Head and neck solitary fibrous tumors demonstrate a significantly larger local recurrence rate as compared with their rate of metastasis. They can recur many years following initial therapy, warranting long-term surveillance and follow-up to assess for tumor recurrence.
UNASSIGNED: Retrospective review.
UNASSIGNED: University of California-Los Angeles Medical Center.
UNASSIGNED: A single-center retrospective study was conducted on pathologically confirmed cases of head and neck solitary fibrous tumors between 1996 and 2021. Patient demographics, clinical course, and histopathologic features were evaluated. Recurrence-free survival was estimated via Kaplan-Meier analysis.
UNASSIGNED: A total of 52 patients were reviewed. The average patient age was 54.7 years (range, 15-89). The most common subsite was the orbit (53.8%, n = 28), but other involved areas included the nasopharynx, paranasal sinuses, and scalp. The median tumor size was 2.95 cm (range, 1.3-11.2). Strong STAT6 (100%) and CD34 (97.9%) expression was observed on immunohistochemistry. Almost all patients were initially managed with wide local excision; 82% of patients (n = 14) had positive margins on pathologic review; and 15% (n = 4) had recurrence at a median 28.5 months (range, 10-113). White patient race was the only significant predictor of tumor recurrence. Patient age (≥55 years), tumor size (≥4), high mitotic rate, and disease subsite were not associated with recurrence.
UNASSIGNED: Head and neck solitary fibrous tumors demonstrate a significantly larger local recurrence rate as compared with their rate of metastasis. They can recur many years following initial therapy, warranting long-term surveillance and follow-up to assess for tumor recurrence.
摘要：
■评估头颈部孤立性纤维瘤的临床病理特征和可能预测肿瘤复发的特征。
■回顾性审查。
加州大学洛杉矶分校医学中心。
■对1996年至2021年间经病理证实的头颈部孤立性纤维瘤病例进行了单中心回顾性研究。患者人口统计学，临床课程，和组织病理学特征进行了评估。通过Kaplan-Meier分析估计无复发生存率。
■共检查52例患者。患者平均年龄为54.7岁（范围，15-89)。最常见的子站点是轨道(53.8%，n=28),但其他涉及的领域包括鼻咽，鼻旁窦,和头皮。中位肿瘤大小为2.95cm（范围，1.3-11.2)。在免疫组织化学上观察到强烈的STAT6(100%)和CD34(97.9%)表达。几乎所有患者最初都进行了广泛的局部切除术；82％的患者（n=14）在病理检查中具有阳性切缘；15％（n=4）在中位28.5个月时复发（范围，10-113)。白种人是肿瘤复发的唯一重要预测因素。患者年龄（≥55岁），肿瘤大小（≥4），高有丝分裂率，疾病亚位点与复发无关。
■头颈部孤立性纤维瘤的局部复发率明显高于其转移率。他们可以在初始治疗后复发很多年，保证长期监测和随访以评估肿瘤复发。
■回顾性审查。
加州大学洛杉矶分校医学中心。
■对1996年至2021年间经病理证实的头颈部孤立性纤维瘤病例进行了单中心回顾性研究。患者人口统计学，临床课程，和组织病理学特征进行了评估。通过Kaplan-Meier分析估计无复发生存率。
■共检查52例患者。患者平均年龄为54.7岁（范围，15-89)。最常见的子站点是轨道(53.8%，n=28),但其他涉及的领域包括鼻咽，鼻旁窦,和头皮。中位肿瘤大小为2.95cm（范围，1.3-11.2)。在免疫组织化学上观察到强烈的STAT6(100%)和CD34(97.9%)表达。几乎所有患者最初都进行了广泛的局部切除术；82％的患者（n=14）在病理检查中具有阳性切缘；15％（n=4）在中位28.5个月时复发（范围，10-113)。白种人是肿瘤复发的唯一重要预测因素。患者年龄（≥55岁），肿瘤大小（≥4），高有丝分裂率，疾病亚位点与复发无关。
■头颈部孤立性纤维瘤的局部复发率明显高于其转移率。他们可以在初始治疗后复发很多年，保证长期监测和随访以评估肿瘤复发。
