%0 Journal Article
%T Solitary Fibrous Tumors of the Head and Neck: A Single-Institution Study of 52 Patients.
%A Chung HR
%A Tam K
%A Han AY
%A Obeidin F
%A Nakasaki M
%A Chhetri DK
%A St John MA
%A Kita AE
%A Chung HR
%A Tam K
%A Han AY
%A Obeidin F
%A Nakasaki M
%A Chhetri DK
%A St John MA
%A Kita AE
%J OTO Open
%V 6
%N 3
%D Jul-Sep 2022
%M 35845143
暂无%R 10.1177/2473974X221098709
%X UNASSIGNED: To evaluate the clinicopathologic characteristics of head and neck solitary fibrous tumors and features that may predict tumor recurrence.
UNASSIGNED: Retrospective review.
UNASSIGNED: University of California-Los Angeles Medical Center.
UNASSIGNED: A single-center retrospective study was conducted on pathologically confirmed cases of head and neck solitary fibrous tumors between 1996 and 2021. Patient demographics, clinical course, and histopathologic features were evaluated. Recurrence-free survival was estimated via Kaplan-Meier analysis.
UNASSIGNED: A total of 52 patients were reviewed. The average patient age was 54.7 years (range, 15-89). The most common subsite was the orbit (53.8%, n = 28), but other involved areas included the nasopharynx, paranasal sinuses, and scalp. The median tumor size was 2.95 cm (range, 1.3-11.2). Strong STAT6 (100%) and CD34 (97.9%) expression was observed on immunohistochemistry. Almost all patients were initially managed with wide local excision; 82% of patients (n = 14) had positive margins on pathologic review; and 15% (n = 4) had recurrence at a median 28.5 months (range, 10-113). White patient race was the only significant predictor of tumor recurrence. Patient age (≥55 years), tumor size (≥4), high mitotic rate, and disease subsite were not associated with recurrence.
UNASSIGNED: Head and neck solitary fibrous tumors demonstrate a significantly larger local recurrence rate as compared with their rate of metastasis. They can recur many years following initial therapy, warranting long-term surveillance and follow-up to assess for tumor recurrence.