Abstract：
Acne is the most common skin disorder which is known as a chronic inflammatory disease with psychological burden and reduced quality of life. Adipose tissue-derived stromal vascular fraction (SVF) is recognized as a source of regenerative cells and improves the quality of skin by increasing collagen content. To date, a few studies have been performed on the therapeutic role of SVF in the treatment of acne scars.
This randomized, single-blinded clinical trial was performed on 7 patients with acne scars. In all patients, the initial grade of acne (volume, area and depth) was evaluated and ultrasound of the relevant scar was performed to evaluate neocollagenesis. As a spilt face study, for treating the scars, we used nanofat subcutaneously on one side of the face (control group) and combination of nanofat subcutaneously and SVF intradermally on the opposite side (intervention group). The patients were evaluated for severity of acne by visioface after one month, also for thickness of epidermis and dermis by ultrasound after one month and three months.
All of the apparent findings of scars improved in two groups after one month, but these changes were significant just for the group treated with SVF (p value < 0.05). Epidermal, dermal and complete thicknesses during the first month in both control and intervention groups were significantly increased (p value < 0.05) but between the first and third months, there was no significant difference in the variables (p value > 0.05). The findings showed that dermal and complete thicknesses of the skin in the first month were different between two groups significantly (p value: 0.042 and 0.040, respectively).
The use of SVF in the treatment of patients with acne scars accelerates the improvement of volume, area and depth of the scar by increasing collagen content and the dermal thickness, so it can be used as a potentially effective treatment for these patients.
This randomized, single-blinded clinical trial was performed on 7 patients with acne scars. In all patients, the initial grade of acne (volume, area and depth) was evaluated and ultrasound of the relevant scar was performed to evaluate neocollagenesis. As a spilt face study, for treating the scars, we used nanofat subcutaneously on one side of the face (control group) and combination of nanofat subcutaneously and SVF intradermally on the opposite side (intervention group). The patients were evaluated for severity of acne by visioface after one month, also for thickness of epidermis and dermis by ultrasound after one month and three months.
All of the apparent findings of scars improved in two groups after one month, but these changes were significant just for the group treated with SVF (p value < 0.05). Epidermal, dermal and complete thicknesses during the first month in both control and intervention groups were significantly increased (p value < 0.05) but between the first and third months, there was no significant difference in the variables (p value > 0.05). The findings showed that dermal and complete thicknesses of the skin in the first month were different between two groups significantly (p value: 0.042 and 0.040, respectively).
The use of SVF in the treatment of patients with acne scars accelerates the improvement of volume, area and depth of the scar by increasing collagen content and the dermal thickness, so it can be used as a potentially effective treatment for these patients.
摘要：
痤疮是最常见的皮肤病，被称为慢性炎症性疾病，具有心理负担和生活质量下降。脂肪组织来源的基质血管部分（SVF）被认为是再生细胞的来源，并通过增加胶原蛋白含量来改善皮肤质量。迄今为止,已经对SVF在治疗痤疮疤痕中的治疗作用进行了一些研究。
这是随机的，对7例痤疮瘢痕患者进行了单盲临床试验.在所有患者中，痤疮的初始等级(体积，面积和深度）进行评估，并对相关瘢痕进行超声检查以评估新生。作为一个洒脸的研究，为了治疗疤痕，我们在面部一侧皮下使用nanofat（对照组），在另一侧皮下使用nanofat和SVF皮内联合使用（干预组）。一个月后通过外观评估患者痤疮的严重程度，还通过一个月和三个月后的超声检查表皮和真皮的厚度。
两组患者1个月后所有明显的疤痕改善，但是这些变化对于用SVF治疗的组来说是显著的(p值<0.05)。表皮,在第一个月，对照组和干预组的皮肤和完全厚度均显着增加（p值<0.05），但在第一个月和第三个月之间，各变量无显著差异(p值>0.05)。研究结果表明，第一个月的皮肤厚度和皮肤完全厚度在两组之间显着不同（p值分别为0.042和0.040）。
在痤疮疤痕患者的治疗中使用SVF加速了体积的改善，通过增加胶原蛋白含量和真皮厚度，因此，它可以用作这些患者的潜在有效治疗方法。
这是随机的，对7例痤疮瘢痕患者进行了单盲临床试验.在所有患者中，痤疮的初始等级(体积，面积和深度）进行评估，并对相关瘢痕进行超声检查以评估新生。作为一个洒脸的研究，为了治疗疤痕，我们在面部一侧皮下使用nanofat（对照组），在另一侧皮下使用nanofat和SVF皮内联合使用（干预组）。一个月后通过外观评估患者痤疮的严重程度，还通过一个月和三个月后的超声检查表皮和真皮的厚度。
两组患者1个月后所有明显的疤痕改善，但是这些变化对于用SVF治疗的组来说是显著的(p值<0.05)。表皮,在第一个月，对照组和干预组的皮肤和完全厚度均显着增加（p值<0.05），但在第一个月和第三个月之间，各变量无显著差异(p值>0.05)。研究结果表明，第一个月的皮肤厚度和皮肤完全厚度在两组之间显着不同（p值分别为0.042和0.040）。
在痤疮疤痕患者的治疗中使用SVF加速了体积的改善，通过增加胶原蛋白含量和真皮厚度，因此，它可以用作这些患者的潜在有效治疗方法。
