PDF(Pubmed)
Abstract：
Valvular heart disease is currently a common problem which causes high morbidity and mortality worldwide. Prosthetic valve replacements are widely needed to correct narrowing or backflow through the valvular orifice. Compared to mechanical valves and biological valves, tissue-engineered heart valves can be an ideal substitute because they have a low risk of thromboembolism and calcification, and the potential for remodelling, regeneration, and growth. In order to test the performance of these heart valves, various animal models and other models are needed to optimise the structure and function of tissue-engineered heart valves, which may provide a potential mechanism responsible for substantial enhancement in tissue-engineered heart valves. Choosing the appropriate model for evaluating the performance of the tissue-engineered valve is important, as different models have their own advantages and disadvantages. In this review, we summarise the current state-of-the-art animal models, bioreactors, and computational simulation models with the aim of creating more strategies for better development of tissue-engineered heart valves. This review provides an overview of major factors that influence the selection and design of a model for tissue-engineered heart valve. Continued efforts in improving and testing models for valve regeneration remain crucial in basic science and translational researches. Future research should focus on finding the right animal model and developing better in vitro testing systems for tissue-engineered heart valve.
摘要：
心脏瓣膜病是目前在全球范围内引起高发病率和死亡率的常见问题。广泛需要假体瓣膜置换以校正通过瓣膜孔口的变窄或回流。与机械阀和生物阀相比，组织工程心脏瓣膜可能是理想的替代品，因为它们具有低的血栓栓塞和钙化风险，以及改造的潜力，再生,和增长。为了测试这些心脏瓣膜的性能，需要各种动物模型和其他模型来优化组织工程心脏瓣膜的结构和功能，这可能提供了一个潜在的机制，负责组织工程心脏瓣膜的实质性增强。选择合适的模型来评估组织工程瓣膜的性能是重要的,因为不同的模型有自己的优点和缺点。在这次审查中,我们总结了当前最先进的动物模型，生物反应器,和计算仿真模型，目的是为更好地开发组织工程心脏瓣膜创造更多的策略。这篇综述概述了影响组织工程心脏瓣膜模型选择和设计的主要因素。在基础科学和转化研究中，继续努力改进和测试阀门再生模型仍然至关重要。未来的研究应该集中在寻找合适的动物模型和开发更好的组织工程心脏瓣膜体外测试系统。
