Abstract：
The major challenges of photothermal therapy (PTT) toward clinical application are the severe skin injury and inflammation response associated with high power laser irradiation. Herein, polydopamine nanoparticles (PDA-EST and PDA-RAL) targeted to estrogen receptor α (ERα) for efficient ablation of breast tumor under a low irradiation density of 0.1 W cm-2 are reported. These nanoparticles are capable of recruiting ERα on their surface and induce a complete ERα degradation via localized heat. Owing to the ERα targetability, PDA-EST and PDA-RAL strongly suppress the proliferation of breast cancer cells without causing significant inflammation. This work provides a generalized method for enhancing PTT efficacy under low irradiation density.
摘要：
光热疗法（PTT）对临床应用的主要挑战是与高功率激光照射相关的严重皮肤损伤和炎症反应。在这里，据报道，靶向雌激素受体α（ERα）的聚多巴胺纳米颗粒（PDA-EST和PDA-RAL）可在0.1Wcm-2的低辐射密度下有效消融乳腺肿瘤。这些纳米颗粒能够在其表面上募集ERα，并通过局部加热诱导完全的ERα降解。由于ERα的靶向性，PDA-EST和PDA-RAL强烈抑制乳腺癌细胞的增殖而不引起明显的炎症。这项工作提供了一种在低辐照密度下增强PTT功效的通用方法。
