%0 Journal Article
%T Targeted Recruitment and Degradation of Estrogen Receptor α by Photothermal Polydopamine Nanoparticles for Breast Tumor Ablation.
%A Zhang Y
%A Ding X
%A Xie F
%A Gao M
%A Qiu J
%A Wang Z
%A Qing L
%A Yan J
%A Peng N
%A Li Y
%A Xu J
%A Cai Q
%A Jin Y
%A Jiao Y
%A Liu Y
%A He H
%A Zhang S
%J Adv Healthc Mater
%V 11
%N 19
%D 10 2022
%M 35833876
%F 11.092
%R 10.1002/adhm.202200960
%X The major challenges of photothermal therapy (PTT) toward clinical application are the severe skin injury and inflammation response associated with high power laser irradiation. Herein, polydopamine nanoparticles (PDA-EST and PDA-RAL) targeted to estrogen receptor α (ERα) for efficient ablation of breast tumor under a low irradiation density of 0.1 W cm-2 are reported. These nanoparticles are capable of recruiting ERα on their surface and induce a complete ERα degradation via localized heat. Owing to the ERα targetability, PDA-EST and PDA-RAL strongly suppress the proliferation of breast cancer cells without causing significant inflammation. This work provides a generalized method for enhancing PTT efficacy under low irradiation density.