Abstract：
BACKGROUND: Cannabinoid-based therapy has been shown to be promising and is emerging as crucial for the treatment of cognitive deficits, mental illnesses, and many diseases considered incurable. There is a need to find an appropriate therapy for Alzheimer\'s disease, and cannabinoid-based therapy appears to be a feasible possibility.
METHODS: This report addresses the beneficial effect of cannabinoids in microdoses on improving memory and brain functions of a patient with mild-stage Alzheimer\'s disease. The patient is a 75-year-old white man presenting with main symptoms of memory deficit, spatial and temporal disorientation, and limited daily activity. The experimental therapeutic intervention was carried out for 22 months with microdoses of a cannabis extract containing cannabinoids. Clinical evaluations using Mini-Mental State Examination and Alzheimer\'s Disease Assessment Scale-Cognitive Subscale were performed.
CONCLUSIONS: Here we provide original evidence that cannabinoid microdosing could be effective as an Alzheimer\'s disease treatment while preventing major side effects. This is an important step toward dissociating cannabinoids\' health-improving effects from potential narcotic-related limitations.
METHODS: This report addresses the beneficial effect of cannabinoids in microdoses on improving memory and brain functions of a patient with mild-stage Alzheimer\'s disease. The patient is a 75-year-old white man presenting with main symptoms of memory deficit, spatial and temporal disorientation, and limited daily activity. The experimental therapeutic intervention was carried out for 22 months with microdoses of a cannabis extract containing cannabinoids. Clinical evaluations using Mini-Mental State Examination and Alzheimer\'s Disease Assessment Scale-Cognitive Subscale were performed.
CONCLUSIONS: Here we provide original evidence that cannabinoid microdosing could be effective as an Alzheimer\'s disease treatment while preventing major side effects. This is an important step toward dissociating cannabinoids\' health-improving effects from potential narcotic-related limitations.
摘要：
背景：基于大麻素的治疗已被证明是有前途的，并且正在成为治疗认知缺陷的关键，精神疾病,和许多疾病被认为是无法治愈的。需要找到一种治疗阿尔茨海默病的适当方法,和基于大麻素的治疗似乎是一个可行的可能性。
方法：本报告阐述了微剂量大麻素对改善轻度阿尔茨海默病患者记忆和脑功能的有益作用。患者是一名75岁的白人男性，表现为记忆障碍的主要症状，空间和时间的迷失方向，有限的日常活动。使用微剂量的含有大麻素的大麻提取物进行22个月的实验性治疗干预。使用简易精神状态检查和阿尔茨海默病评估量表-认知子量表进行临床评估。
结论：在这里，我们提供了原始证据，证明大麻素微剂量可以有效地治疗阿尔茨海默病，同时防止主要副作用。这是朝着从潜在的麻醉相关限制中分离大麻素改善健康的作用迈出的重要一步。
方法：本报告阐述了微剂量大麻素对改善轻度阿尔茨海默病患者记忆和脑功能的有益作用。患者是一名75岁的白人男性，表现为记忆障碍的主要症状，空间和时间的迷失方向，有限的日常活动。使用微剂量的含有大麻素的大麻提取物进行22个月的实验性治疗干预。使用简易精神状态检查和阿尔茨海默病评估量表-认知子量表进行临床评估。
结论：在这里，我们提供了原始证据，证明大麻素微剂量可以有效地治疗阿尔茨海默病，同时防止主要副作用。这是朝着从潜在的麻醉相关限制中分离大麻素改善健康的作用迈出的重要一步。
