PDF(Pubmed)
Abstract：
UNASSIGNED: Long-acting injectable antipsychotics (LAI - APs) improve adherence to antipsychotics and decrease functional decline in schizophrenia. Yet they are prescribed late, in patients with established functional decline. Although LAI - APs are widely prescribed in South Africa, there is a paucity of research regarding the prescription profile for LAI - APs.
UNASSIGNED: This study aimed to describe prescribing practices for LAI - APs at psychiatric clinics.
UNASSIGNED: Community psychiatric clinics in South Africa.
UNASSIGNED: A retrospective review of the psychiatric files of all patients on LAI - APs attending the clinics over the study period was conducted. Sociodemographic, clinical and pharmacological information regarding the LAI - AP prescribed was extracted from the files.
UNASSIGNED: A total of 206 charts were examined. The mean age of the study population was 46 (SD ± 12) years. Significantly more patients were male (n = 154; 74.8%), single (n = 184, 89.3%) and unemployed (n = 115; 55.8%) (p < 0.001). Approximately half had a comorbid substance use disorder (47.6%). The most common indication for the prescription of a LAI - AP was non-adherence (66%). Only 9.7% of the patients were prescribed a LAI - AP alone. No significant socio-demographic or clinical characteristic was associated with this prescribing habit. A LAI - AP was prescribed in combination with an oral antipsychotic, mood stabiliser or antidepressant in 53.9%, 44.7% and 7.8% of patients, respectively.
UNASSIGNED: Long-acting injectable antipsychotics were prescribed mainly following noncompliance with oral antipsychotics and may represent a missed opportunity to prevent functional decline. The high prevalence of LAI - AP polypharmacy has been highlighted.
UNASSIGNED: This study aimed to describe prescribing practices for LAI - APs at psychiatric clinics.
UNASSIGNED: Community psychiatric clinics in South Africa.
UNASSIGNED: A retrospective review of the psychiatric files of all patients on LAI - APs attending the clinics over the study period was conducted. Sociodemographic, clinical and pharmacological information regarding the LAI - AP prescribed was extracted from the files.
UNASSIGNED: A total of 206 charts were examined. The mean age of the study population was 46 (SD ± 12) years. Significantly more patients were male (n = 154; 74.8%), single (n = 184, 89.3%) and unemployed (n = 115; 55.8%) (p < 0.001). Approximately half had a comorbid substance use disorder (47.6%). The most common indication for the prescription of a LAI - AP was non-adherence (66%). Only 9.7% of the patients were prescribed a LAI - AP alone. No significant socio-demographic or clinical characteristic was associated with this prescribing habit. A LAI - AP was prescribed in combination with an oral antipsychotic, mood stabiliser or antidepressant in 53.9%, 44.7% and 7.8% of patients, respectively.
UNASSIGNED: Long-acting injectable antipsychotics were prescribed mainly following noncompliance with oral antipsychotics and may represent a missed opportunity to prevent functional decline. The high prevalence of LAI - AP polypharmacy has been highlighted.
摘要：
■长效注射抗精神病药（LAI-AP）可提高抗精神病药的依从性并减少精神分裂症的功能衰退。然而他们被规定得很晚，在建立功能衰退的患者中。尽管LAI-AP在南非被广泛规定，关于LAI-AP处方概况的研究很少。
■本研究旨在描述精神病诊所LAI-AP的处方实践。
■南非的社区精神病诊所。
■对研究期间就诊于诊所的所有LAI-AP患者的精神病档案进行回顾性审查。社会人口统计学，从文件中提取有关LAI-AP处方的临床和药理学信息.
■共检查了206张图表。研究人群的平均年龄为46(SD±12)岁。男性患者明显增多（n=154；74.8%），单身(n=184，89.3%)和失业(n=115；55.8%)(p<0.001)。大约一半患有合并症的物质使用障碍（47.6％）。LAI-AP处方的最常见适应症是不依从性（66％）。只有9.7％的患者单独使用LAI-AP。没有显著的社会人口统计学或临床特征与这种处方习惯相关。LAI-AP与口服抗精神病药联合使用，53.9%的情绪稳定剂或抗抑郁药，44.7％和7.8％的患者，分别。
■长效注射抗精神病药的处方主要是在口服抗精神病药不依从的情况下，这可能是预防功能下降的错失机会。LAI-AP多重用药的高患病率已得到强调。
■本研究旨在描述精神病诊所LAI-AP的处方实践。
■南非的社区精神病诊所。
■对研究期间就诊于诊所的所有LAI-AP患者的精神病档案进行回顾性审查。社会人口统计学，从文件中提取有关LAI-AP处方的临床和药理学信息.
■共检查了206张图表。研究人群的平均年龄为46(SD±12)岁。男性患者明显增多（n=154；74.8%），单身(n=184，89.3%)和失业(n=115；55.8%)(p<0.001)。大约一半患有合并症的物质使用障碍（47.6％）。LAI-AP处方的最常见适应症是不依从性（66％）。只有9.7％的患者单独使用LAI-AP。没有显著的社会人口统计学或临床特征与这种处方习惯相关。LAI-AP与口服抗精神病药联合使用，53.9%的情绪稳定剂或抗抑郁药，44.7％和7.8％的患者，分别。
■长效注射抗精神病药的处方主要是在口服抗精神病药不依从的情况下，这可能是预防功能下降的错失机会。LAI-AP多重用药的高患病率已得到强调。
