Abstract：
Plastic pollution is a serious problem in aquatic systems throughout the world. Despite the increasing number of studies addressing the impact of macro- and microplastics on biota, there is still a significant knowledge gap regarding the effects of nanoplastics alone and in combination with other contaminants. Among the aquatic contaminants that may interact with nanoplastics is arsenic (As), a metalloid found in estuarine and coastal ecosystems, pernicious to benthic organisms. This study aimed to understand how a parental pre-exposure to 100 nm polystyrene nanoplastics (PS NPs) would influence the response of Hediste diversicolor to exposure to arsenic in terms of behaviour, neurotransmission, antioxidant defences and oxidative damage, and energy metabolism. The obtained data revealed an increase in burrowing time and a significant inhibition in cholinesterase activity in all polychaetes exposed to As, regardless of the pre-exposure to PS NPs. Oxidative status was altered particularly in parentally exposed organisms, with damage detected in terms of lipid peroxidation at 50 μg/L and protein carbonylation at 50 and 250 μg As/L exposed organisms when compared to control. Overall, data shows that parental pre-exposure to plastics influences the response of aquatic organisms, increasing their susceptibility to other contaminants. Thus, more studies should be performed with other environmental contaminants, to better understand the potential increased risk associated with the presence of nanoplastics to aquatic ecosystems.
摘要：
塑料污染是全世界水生系统中的一个严重问题。尽管越来越多的研究涉及宏观和微塑料对生物群的影响，关于纳米塑料单独和与其他污染物结合的影响，仍然存在显著的知识差距。可能与纳米塑料相互作用的水生污染物是砷（As），在河口和沿海生态系统中发现的准金属，对底栖生物有害。这项研究旨在了解父母预暴露于100nm聚苯乙烯纳米塑料（PSNPs）将如何影响Hedisediversicolor对暴露于砷的行为反应，神经传递,抗氧化防御和氧化损伤，和能量代谢。获得的数据表明，在暴露于As的所有多毛菌中，挖洞时间增加，胆碱酯酶活性受到显着抑制，无论预先暴露于PSNP。氧化状态发生了改变，特别是在肠胃外暴露的生物体中，与对照相比，以50μg/L的脂质过氧化和50和250μgAs/L的蛋白质羰基化检测到的损害。总的来说,数据显示，父母预接触塑料会影响水生生物的反应，增加他们对其他污染物的敏感性。因此，应该对其他环境污染物进行更多的研究，更好地了解与纳米塑料对水生生态系统的存在相关的潜在风险增加。
