Abstract：
Ischemic stroke is the main cause of permanent disability in adult patients. No commonly accepted method were discovered to predict stroke before the first symptoms. Activation of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMP) and S100B protein may be observe in patients with symptomatic carotid artery stenosis. Hemorrhagic transformation of ischemic stroke may be associated with changes in MMP, TIMP and S100B.
OBJECTIVE: The aim of this study was to determine if MMP-9, TIMP-1 and S-100B protein may markers of forthcoming ischemic stroke in patients undergoing carotid endarterectomy.
METHODS: Blood samples were taken and an analysis of circulating proteins (MMP-9, TIMP-1, S100B) 73 subsequent patients with carotid artery stenosis ≥70% (33 asymptomatic and 40 symptomatic), who were referred for potential revascularization.
RESULTS: A statistically significant difference was found between MMP- 9 levels in patients with ischemic stroke compared to patients with asymptomatic carotid stenosis after endarterectomy. Also, average TIMP-1 levels in patients with ischemic stroke and stenosis ≥70% were statistically significantly higher than the average levels in patients after endarterectomy. In terms of S-100B, a higher mean value was observed in patients with stroke than in endarterectomy group. No statistical differences were found in the levels of that proteins in the hemorrhagic transformation of ischemic stroke.
CONCLUSIONS: Increased levels of MMP-9, TIMP-1 and S-100B in patients with ischemic stroke compared to patients with asymptomatic carotid stenosis after endarterectomy showed that abovementioned proteins may be a good predictive factor of ischemic stroke in patients undergoing carotid endarterectomy.
OBJECTIVE: The aim of this study was to determine if MMP-9, TIMP-1 and S-100B protein may markers of forthcoming ischemic stroke in patients undergoing carotid endarterectomy.
METHODS: Blood samples were taken and an analysis of circulating proteins (MMP-9, TIMP-1, S100B) 73 subsequent patients with carotid artery stenosis ≥70% (33 asymptomatic and 40 symptomatic), who were referred for potential revascularization.
RESULTS: A statistically significant difference was found between MMP- 9 levels in patients with ischemic stroke compared to patients with asymptomatic carotid stenosis after endarterectomy. Also, average TIMP-1 levels in patients with ischemic stroke and stenosis ≥70% were statistically significantly higher than the average levels in patients after endarterectomy. In terms of S-100B, a higher mean value was observed in patients with stroke than in endarterectomy group. No statistical differences were found in the levels of that proteins in the hemorrhagic transformation of ischemic stroke.
CONCLUSIONS: Increased levels of MMP-9, TIMP-1 and S-100B in patients with ischemic stroke compared to patients with asymptomatic carotid stenosis after endarterectomy showed that abovementioned proteins may be a good predictive factor of ischemic stroke in patients undergoing carotid endarterectomy.
摘要：
缺血性卒中是成人患者永久性残疾的主要原因。没有发现普遍接受的方法来预测最初症状之前的中风。基质金属蛋白酶（MMPs）的激活，在症状性颈动脉狭窄患者中可观察到金属蛋白酶组织抑制因子(TIMP)和S100B蛋白。缺血性脑卒中的出血性转化可能与MMP、TIMP和S100B。
目的：本研究的目的是确定MMP-9，TIMP-1和S-100B蛋白是否可能是颈动脉内膜切除术患者即将发生的缺血性卒中的标志物。
方法：采集血样并分析循环蛋白（MMP-9，TIMP-1，S100B）73例颈动脉狭窄≥70％（33例无症状，40例有症状），他们因潜在的血运重建而被转诊。
结果：与动脉内膜切除术后无症状颈动脉狭窄患者相比，缺血性卒中患者的MMP-9水平存在统计学上的显着差异。此外，缺血性卒中和狭窄≥70%患者的平均TIMP-1水平在统计学上显著高于动脉内膜切除术后患者的平均水平.就S-100B而言，卒中患者的平均值高于动脉内膜切除术组.在缺血性中风的出血性转化中，这些蛋白质的水平没有统计学差异。
结论：与动脉内膜切除术后无症状颈动脉狭窄患者相比，缺血性卒中患者MMP-9、TIMP-1和S-100B水平升高，提示上述蛋白可能是颈动脉内膜切除术患者发生缺血性卒中的良好预测因素。
目的：本研究的目的是确定MMP-9，TIMP-1和S-100B蛋白是否可能是颈动脉内膜切除术患者即将发生的缺血性卒中的标志物。
方法：采集血样并分析循环蛋白（MMP-9，TIMP-1，S100B）73例颈动脉狭窄≥70％（33例无症状，40例有症状），他们因潜在的血运重建而被转诊。
结果：与动脉内膜切除术后无症状颈动脉狭窄患者相比，缺血性卒中患者的MMP-9水平存在统计学上的显着差异。此外，缺血性卒中和狭窄≥70%患者的平均TIMP-1水平在统计学上显著高于动脉内膜切除术后患者的平均水平.就S-100B而言，卒中患者的平均值高于动脉内膜切除术组.在缺血性中风的出血性转化中，这些蛋白质的水平没有统计学差异。
结论：与动脉内膜切除术后无症状颈动脉狭窄患者相比，缺血性卒中患者MMP-9、TIMP-1和S-100B水平升高，提示上述蛋白可能是颈动脉内膜切除术患者发生缺血性卒中的良好预测因素。
