PDF(Pubmed)
Abstract：
Managing epilepsy in people with an intellectual disability remains a therapeutic challenge and must take into account additional issues such as diagnostic difficulties and frequent drug resistance. Advances in genomic technologies improved our understanding of epilepsy and raised the possibility to develop patients-tailored treatments acting on the key molecular mechanisms involved in the development of the disease. In addition to conventional antiseizure medications (ASMs), ketogenic diet, hormone therapy and epilepsy surgery play an important role, especially in cases of drugresistance. This review aims to provide a comprehensive overview of the mainfactors influencing cognition in children and adolescents with epilepsy and the main therapeutic options available for the epilepsies associated with intellectual disability.
摘要：
在智障人士中管理癫痫仍然是一个治疗挑战，必须考虑到其他问题，如诊断困难和频繁的耐药性。基因组技术的进步提高了我们对癫痫的理解，并提高了开发针对患者量身定制的治疗方法的可能性，这些治疗方法对疾病发展中涉及的关键分子机制起作用。除了常规的抗癫痫药物（ASM），生酮饮食，激素治疗和癫痫手术起着重要的作用，尤其是在耐药的情况下。这篇综述旨在全面概述影响儿童和青少年癫痫患者认知的主要因素以及与智力障碍相关的癫痫患者的主要治疗选择。
