Abstract：
Laryngeal leukoplakia is a common disorder in otolaryngology. Presently, the most widely accepted treatment is suspension laryngoscopic surgery under general anesthesia. The high recurrence rate and hoarse voice after surgery make it an intractable disease to treat. Here we report a case of a 67-year-old man who was diagnosed of laryngeal leukoplakia 15 years ago and underwent 5 surgeries because of its repeated recurrences. Two sessions of photodynamic therapy were performed with local application of 5-aminolevulinic acid and irradiation of 635 nm diode laser. Complete response was observed and no recurrence was detected during follow-up of 6 months. Photodynamic therapy with local 5-ALA application and 635 nm laser is safe and well-tolerated. It is a promising modality for laryngeal leukoplakia.
摘要：
喉白斑是耳鼻咽喉科常见疾病。目前,最广泛接受的治疗是全身麻醉下的喉镜悬吊术。手术后高复发率和声音嘶哑使其成为难以治疗的疾病。在这里，我们报告了一例67岁的男子，他在15年前被诊断出喉白斑，并因反复复发而接受了5次手术。局部应用5-氨基乙酰丙酸和635nm二极管激光照射进行了两次光动力治疗。观察到完全缓解，在6个月的随访中没有发现复发。使用局部5-ALA应用和635nm激光的光动力疗法是安全且耐受性良好的。这是一种很有前途的喉白斑方式。
