Abstract：
Mongolian horses have been bred and used for labor and transport for centuries. Nevertheless, traits of testicular development in Mongolian horses have rarely been studied; particularly, studies regarding the transcriptional regulation characteristics of testicular development are lacking. In this paper, transcription specificity during testicular development in Mongolian horses is highlighted via a multispecies comparative analysis and weighted gene co-expression network analysis (WGCNA). Interestingly, the results showed that most genes were up-regulated in the testes after sexual maturity, which is a phenomenon conserved across species. Moreover, we observed nine key genes involved in regulating Mongolian horse testicular development. Notably, unique transcription signatures of testicular development in Mongolian horses are emphasized, which provides a novel insight into the mechanistic study of their testicular development.
摘要：
几个世纪以来，蒙古马一直被饲养和用于劳动和运输。然而，蒙古马睾丸发育的特征很少被研究；特别是，缺乏有关睾丸发育转录调控特征的研究。在本文中,通过多物种比较分析和加权基因共表达网络分析（WGCNA）强调了蒙古马睾丸发育过程中的转录特异性。有趣的是,结果表明，大多数基因在性成熟后在睾丸中上调，这是一种跨物种保守的现象。此外，我们观察到了9个参与调节蒙古马睾丸发育的关键基因。值得注意的是,强调了蒙古马睾丸发育的独特转录特征，这为他们的睾丸发育机理研究提供了新的见解。
