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Abstract：
Occupational exposure to carcinogens is associated with trachea, bronchus, and lung (TBL) cancer. The objective of this study was to provide global and regional estimates of the burden of TBL cancer associated with occupational carcinogens (OCs) between 1990 and 2019.
Age-standardized mortality rates (ASMR) and age-standardized disability-adjusted life years (DALYs) rates (ASDR) of TBL cancer related to exposure to OCs at the global and regional levels were extracted for 1990-2019 from the Global Burden of Disease 2019. Joinpoint regression was used to analyze trends in the ASMR and ASDR of TBL cancer burden related to OCs, and the annual percent change and the average annual percent change (AAPC) were recorded.
The mortality from TBL cancer related to exposure to OCs increased globally. The ASMR and ASDR decreased in both sexes and in men between 1990 and 2019. The AAPC of ASMR and ASDR decreased in men between 1990 and 2019, but increased in women. Asbestos accounted for the highest death number and beryllium accounted for the lowest; diesel engine exhaust caused the largest percentage change in death number (145.3%), in ASDR (14.9%), and in all ages DALY rates (57.6%). Asbestos accounted for the largest death number in high social development index (SDI) countries, whereas low-middle SDI countries had the largest percent change (321.4%). Asbestos was associated with decreased ASDR in high SDI countries and increased ASDR in low-middle SDI countries, and similar changes were observed for other OCs.
The overall mortality and DALYs of TBL cancer burden related to OCs showed a decreasing trend between 1990 and 2019, whereas death number increased. Asbestos accounted for the highest death number. TBL cancer burden related to OCs decreased to different degrees in high, low, low-middle, and middle SDI countries, which showed variable levels of TBL cancer burden related to exposure to OCs (except asbestos).
Age-standardized mortality rates (ASMR) and age-standardized disability-adjusted life years (DALYs) rates (ASDR) of TBL cancer related to exposure to OCs at the global and regional levels were extracted for 1990-2019 from the Global Burden of Disease 2019. Joinpoint regression was used to analyze trends in the ASMR and ASDR of TBL cancer burden related to OCs, and the annual percent change and the average annual percent change (AAPC) were recorded.
The mortality from TBL cancer related to exposure to OCs increased globally. The ASMR and ASDR decreased in both sexes and in men between 1990 and 2019. The AAPC of ASMR and ASDR decreased in men between 1990 and 2019, but increased in women. Asbestos accounted for the highest death number and beryllium accounted for the lowest; diesel engine exhaust caused the largest percentage change in death number (145.3%), in ASDR (14.9%), and in all ages DALY rates (57.6%). Asbestos accounted for the largest death number in high social development index (SDI) countries, whereas low-middle SDI countries had the largest percent change (321.4%). Asbestos was associated with decreased ASDR in high SDI countries and increased ASDR in low-middle SDI countries, and similar changes were observed for other OCs.
The overall mortality and DALYs of TBL cancer burden related to OCs showed a decreasing trend between 1990 and 2019, whereas death number increased. Asbestos accounted for the highest death number. TBL cancer burden related to OCs decreased to different degrees in high, low, low-middle, and middle SDI countries, which showed variable levels of TBL cancer burden related to exposure to OCs (except asbestos).
摘要：
职业性接触致癌物与气管有关,支气管,肺癌（TBL）。这项研究的目的是提供1990年至2019年间与职业性致癌物（OC）相关的TBL癌症负担的全球和地区估计。
从《全球疾病负担2019》中提取了1990-2019年全球和区域水平与暴露于OC相关的TBL癌症的年龄标准化死亡率（ASMR）和年龄标准化残疾调整寿命年（DALYs）率（ASDR）。Joinpoint回归用于分析与OCs相关的TBL癌症负荷的ASMR和ASDR趋势，并记录年度百分比变化和平均年度百分比变化（AAPC）。
与暴露于OCs相关的TBL癌症的死亡率在全球范围内增加。在1990年至2019年期间，男女和男性的ASMR和ASDR均下降。在1990年至2019年期间，男性ASMR和ASDR的AAPC下降，但女性增加。石棉死亡人数最高，铍死亡人数最低；柴油机尾气造成死亡人数变化百分比最大(145.3%)，ASDR（14.9%），所有年龄段的DALY率（57.6%）。在高社会发展指数（SDI）国家中，石棉的死亡人数最多，而中低端SDI国家的百分比变化最大(321.4%)。石棉与高SDI国家的ASDR减少有关，与低SDI国家的ASDR增加有关，其他OCs也观察到类似的变化。
在1990年至2019年期间，与OCs相关的TBL癌症负担的总死亡率和DALYs呈下降趋势，而死亡人数有所增加。石棉的死亡人数最高。与OCs相关的TBL癌症负担在不同程度上下降，低,中低端,和SDI中间国家，显示与暴露于OCs（石棉除外）相关的TBL癌症负担水平不同。
从《全球疾病负担2019》中提取了1990-2019年全球和区域水平与暴露于OC相关的TBL癌症的年龄标准化死亡率（ASMR）和年龄标准化残疾调整寿命年（DALYs）率（ASDR）。Joinpoint回归用于分析与OCs相关的TBL癌症负荷的ASMR和ASDR趋势，并记录年度百分比变化和平均年度百分比变化（AAPC）。
与暴露于OCs相关的TBL癌症的死亡率在全球范围内增加。在1990年至2019年期间，男女和男性的ASMR和ASDR均下降。在1990年至2019年期间，男性ASMR和ASDR的AAPC下降，但女性增加。石棉死亡人数最高，铍死亡人数最低；柴油机尾气造成死亡人数变化百分比最大(145.3%)，ASDR（14.9%），所有年龄段的DALY率（57.6%）。在高社会发展指数（SDI）国家中，石棉的死亡人数最多，而中低端SDI国家的百分比变化最大(321.4%)。石棉与高SDI国家的ASDR减少有关，与低SDI国家的ASDR增加有关，其他OCs也观察到类似的变化。
在1990年至2019年期间，与OCs相关的TBL癌症负担的总死亡率和DALYs呈下降趋势，而死亡人数有所增加。石棉的死亡人数最高。与OCs相关的TBL癌症负担在不同程度上下降，低,中低端,和SDI中间国家，显示与暴露于OCs（石棉除外）相关的TBL癌症负担水平不同。
