PDF(Pubmed)
Abstract：
SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus-2) is the most dangerous form of the coronavirus, which causes COVID-19. In patients with severe COVID-19, the immune system becomes markedly overactive. There is evidence that supplementation with select micronutrients may play a role in maintaining immune system function in this patient population. Throughout the COVID-19 pandemic, significant emphasis has been placed on the importance of supplementing critical micronutrients such as Vitamin C and Zinc (Zn) due to their immunomodulatory effects. Viral infections, like COVID-19, increase physiological demand for these micronutrients. Therefore, the purpose of this review was to provide comprehensive information regarding the potential effectiveness of Vitamin C and Zn supplementation during viral infection and specifically COVID-19. This review demonstrated a relation between Vitamin C and Zn deficiency and a reduction in the innate immune response, which can ultimately make patients with COVID-19 more vulnerable to viral infection. As such, adequate intake of Vitamin C and Zn, as an adjunctive therapeutic approach with any necessary pharmacological treatment(s), may be necessary to mitigate the adverse physiological effects of COVID-19. To truly clarify the role of Vitamin C and Zn supplementation in the management of COVID-19, we must wait for the results of ongoing randomized controlled trials. The toxicity of Vitamin C and Zn should also be considered to prevent over-supplementation. Over-supplementation of Vitamin C can lead to oxalate toxicity, while increased Zn intake can reduce immune system function. In summary, Vitamin C and Zn supplementation may be useful in mitigating COVID-19 symptomology.
摘要：
SARS-CoV-2（严重急性呼吸系统综合症-冠状病毒-2）是最危险的冠状病毒形式，导致COVID-19。在患有严重COVID-19的患者中，免疫系统变得明显过度活跃。有证据表明，补充精选的微量营养素可能在维持该患者人群的免疫系统功能方面发挥作用。在整个COVID-19大流行期间，由于维生素C和锌（Zn）的免疫调节作用，人们非常重视补充关键微量营养素的重要性。病毒感染,像COVID-19一样，增加了对这些微量营养素的生理需求。因此,本综述的目的是提供有关病毒感染期间补充维生素C和锌的潜在有效性的全面信息,特别是COVID-19.这篇综述证明了维生素C和锌缺乏与先天免疫反应减少之间的关系。最终会使COVID-19患者更容易受到病毒感染。因此，摄入足够的维生素C和锌，作为任何必要的药物治疗的辅助治疗方法，可能是减轻COVID-19的不良生理影响所必需的。要真正阐明补充维生素C和锌在COVID-19管理中的作用，我们必须等待正在进行的随机对照试验的结果。还应考虑维生素C和锌的毒性以防止过度补充。过度补充维生素C会导致草酸盐毒性，而锌摄入增加会降低免疫系统功能。总之,补充维生素C和锌可能有助于缓解COVID-19症状。
