PDF(Pubmed)
Abstract：
The purpose of this systematic review was to evaluate the effects of physiotherapeutic interventions on biomarkers of neuropathic pain in preclinical models of peripheral neuropathic pain (PNP). The search was performed in Pubmed, Web of Science, EMBASE, Cochrane, Cinhal, Psycinfo, Scopus, Medline, and Science Direct. Studies evaluating any type of physiotherapy intervention for PNP (systemic or traumatic) were included. Eighty-one articles were included in this review. The most common PNP model was chronic constriction injury, and the most frequently studied biomarkers were related to neuro-immune processes. Exercise therapy and Electro-acupuncture were the 2 most frequently studied physiotherapy interventions while acupuncture and joint mobilization were less frequently examined. Most physiotherapeutic interventions modulated the expression of biomarkers related to neuropathic pain. Whereas the results seem promising; they have to be considered with caution due to the high risk of bias of included studies and high heterogeneity of the type and anatomical localization of biomarkers reported. The review protocol is registered on PROSPERO (CRD42019142878). PERSPECTIVE: This article presents the current evidence about physiotherapeutic interventions on biomarkers of neuropathic pain in preclinical models of peripheral neuropathic pain. Existing findings are reviewed, and relevant data are provided on the effectiveness of each physiotherapeutic modality, as well as its certainty of evidence and clinical applicability.
摘要：
这项系统评价的目的是评估物理治疗干预对周围神经性疼痛（PNP）临床前模型中神经性疼痛生物标志物的影响。搜索是在Pubmed中执行的，WebofScience,EMBASE,科克伦,Cinhal,Psycinfo,Scopus,Medline,科学直接。包括评估PNP（系统性或创伤性）的任何类型的物理治疗干预的研究。本评论包括81篇文章。最常见的PNP模型是慢性压迫性损伤，最常研究的生物标志物与神经免疫过程有关。运动疗法和电针是2种最常用的物理疗法干预措施，而针灸和关节动员的检查频率较低。大多数理疗干预调节与神经性疼痛相关的生物标志物的表达。尽管结果似乎很有希望；由于纳入研究的偏倚风险很高，并且报告的生物标志物的类型和解剖定位具有高度异质性，因此必须谨慎考虑。审查协议在PROSPERO(CRD42019142878)上注册。背景：本文介绍了目前关于外周神经性疼痛临床前模型中神经性疼痛生物标志物的物理治疗干预的证据。审查了现有的调查结果，并提供有关每种理疗方式有效性的相关数据，以及其证据的确定性和临床适用性。
