PDF(Pubmed)
Abstract：
UNASSIGNED: Prostate cancer is considered as the second leading cause of cancer related death in men worldwide and the third frequent cancer among Iranian men. Despite the use of PSA as the only biomarker for early diagnosis of prostate cancer, its application in clinical settings is under debate. Therefore, the introduction of new molecular markers for early detection of prostate cancer is needed.
UNASSIGNED: In the present study we intended to evaluate the expression of IGSF1, Wnt5a, FGF14, and ITPR1 in prostate cancer specimens by real time PCR. Biopsy samples of 40 prostate cancer cases and 41 healthy Iranian men were compared to determine the relative gene expression of IGSF1, Wnt5a, FGF14, and ITPR1 by real time PCR.
UNASSIGNED: Our results showed that Wnt5a, FGF14, and IGSF1 were significantly overexpressed in the prostate cancer patients while the mean relative expression of ITPR1 showed a significant decrease in PCa samples compared to healthy controls.
UNASSIGNED: According to results of the present study, the combination panel of IGSF1, Wnt5a, FGF14, and ITPR1 genes could be considered as potential genetic markers for prostate cancer diagnosis. However further studies on larger populations and investigating the clinicopathological relevance of these genes is needed.
UNASSIGNED: In the present study we intended to evaluate the expression of IGSF1, Wnt5a, FGF14, and ITPR1 in prostate cancer specimens by real time PCR. Biopsy samples of 40 prostate cancer cases and 41 healthy Iranian men were compared to determine the relative gene expression of IGSF1, Wnt5a, FGF14, and ITPR1 by real time PCR.
UNASSIGNED: Our results showed that Wnt5a, FGF14, and IGSF1 were significantly overexpressed in the prostate cancer patients while the mean relative expression of ITPR1 showed a significant decrease in PCa samples compared to healthy controls.
UNASSIGNED: According to results of the present study, the combination panel of IGSF1, Wnt5a, FGF14, and ITPR1 genes could be considered as potential genetic markers for prostate cancer diagnosis. However further studies on larger populations and investigating the clinicopathological relevance of these genes is needed.
摘要：
未经证实：前列腺癌被认为是全球男性癌症相关死亡的第二大原因，也是伊朗男性中第三常见的癌症。尽管使用PSA作为前列腺癌早期诊断的唯一生物标志物，它在临床环境中的应用正在争论中。因此,需要引入新的分子标志物用于前列腺癌的早期检测。
UNASSIGNED：在本研究中，我们打算评估IGSF1，Wnt5a，通过实时PCR在前列腺癌标本中的FGF14和ITPR1。比较了40例前列腺癌病例和41例健康伊朗男性的活检样本，以确定IGSF1，Wnt5a的相对基因表达。FGF14和ITPR1通过实时PCR。
未经评估：我们的结果表明，Wnt5a，FGF14和IGSF1在前列腺癌患者中显著过表达,而ITPR1的平均相对表达显示与健康对照相比在PCa样品中显著降低。
未经批准：根据本研究的结果，IGSF1，WNT5a的组合面板，FGF14和ITPR1基因可以被认为是前列腺癌诊断的潜在遗传标记。然而，需要对更大的人群进行进一步的研究，并调查这些基因的临床病理相关性。
UNASSIGNED：在本研究中，我们打算评估IGSF1，Wnt5a，通过实时PCR在前列腺癌标本中的FGF14和ITPR1。比较了40例前列腺癌病例和41例健康伊朗男性的活检样本，以确定IGSF1，Wnt5a的相对基因表达。FGF14和ITPR1通过实时PCR。
未经评估：我们的结果表明，Wnt5a，FGF14和IGSF1在前列腺癌患者中显著过表达,而ITPR1的平均相对表达显示与健康对照相比在PCa样品中显著降低。
未经批准：根据本研究的结果，IGSF1，WNT5a的组合面板，FGF14和ITPR1基因可以被认为是前列腺癌诊断的潜在遗传标记。然而，需要对更大的人群进行进一步的研究，并调查这些基因的临床病理相关性。
