PDF(Pubmed)
Abstract：
Photothermal therapy has the characteristics of minimal invasiveness, controllability, high efficiency, and strong specificity, which can effectively make up for the toxic side effects and tumor resistance caused by traditional drug treatment. However, due to the limited tissue penetration of infrared light, it is difficult to promote and apply in clinical practice. The eye is the only transparent tissue in human, and infrared light can easily penetrate the eye tissue, so it is expected that photothermal therapy can be used to treat fundus diseases. Here in, a new nano-platform assembled by liposome and indocyanine green (ICG) was used to treat retinoblastoma. ICG was assembled in liposomes to overcome some problems of ICG itself. For example, ICG is easily quenched, self-aggregating and instability. Moreover, liposomes can prevent free ICG from being cleared through the systemic circulation. The construction of the nano-platform not only ensured the stability of ICG in vivo, but also realized imaging-guide photothermal therapy, which created a new strategy for the treatment of retinoblastoma.
摘要：
光热疗法具有微创的特点，可控性，效率高,特异性强,能有效弥补传统药物治疗带来的毒副作用和肿瘤耐药性。然而,由于红外光的组织穿透力有限，很难在临床上推广应用。眼睛是人类唯一的透明组织,红外光可以很容易地穿透眼睛组织，因此光热疗法有望用于治疗眼底疾病。在这里，由脂质体和吲哚菁绿(ICG)组装而成的新型纳米平台用于治疗视网膜母细胞瘤.将ICG组装在脂质体中以克服ICG本身的一些问题。例如,ICG很容易淬火，自我聚集和不稳定。此外，脂质体可以防止游离ICG通过体循环被清除。纳米平台的构建不仅保证了ICG在体内的稳定性,而且还实现了成像引导光热治疗，这创造了一种治疗视网膜母细胞瘤的新策略。
