Abstract：
The vimentin (encoded by VIM) is one of the 70 human intermediate filaments (IFs), building highly dynamic and cell-type-specific web networks in the cytoplasm. Vim-/- mice exhibit process defects associated with cell differentiation, which can have implications for understanding cancer and disease. This review showed recent reports from studies that unveiled vimentin intermediate filaments (VIFs) as an essential component of the cytoskeleton, followed by a description of vimentin\'s physiological functions and process reports in VIF signaling pathway and gene network studies. The main focus of the discussion is on vital signaling pathways associated with how VIF coordinates invasion cells and migration. The current research will open up multiple processes to research the function of VIF and other IF proteins in cellular and molecular biology, and they will lead to essential insights into different VIF levels for the invasive metastatic cancer cells. Enrich GO databases used Gene Ontology and Pathway Enrichment Analysis. Estimation with STRING online was to predict the functional and molecular interactions of proteins-protein with Cytoscape analysis to search and select the master genes. Using Cytoscape and STRING analysis, we presented eight genes, RhoA, Smad3, Akt1, Cdk2, Rock1, Rock2, Mapk1, and Mapk8, as the essential protein-protein interaction with vimentin involved in the invasion.
摘要：
波形蛋白（由VIM编码）是70种人类中间丝（IF）之一，在细胞质中建立高度动态和细胞类型特异性的网络。Vim-/-小鼠表现出与细胞分化相关的过程缺陷，这可能对理解癌症和疾病有影响。这篇综述显示了最近的研究报告，这些研究揭示了波形蛋白中间丝（VIF）作为细胞骨架的重要组成部分，随后描述了波形蛋白在VIF信号通路和基因网络研究中的生理功能和过程报道。讨论的主要重点是与VIF如何协调入侵细胞和迁移相关的重要信号通路。目前的研究将开辟多个过程来研究VIF和其他IF蛋白在细胞和分子生物学中的功能，它们将导致对侵袭性转移癌细胞的不同VIF水平的重要见解。EnrichGO数据库使用基因本体论和途径富集分析。STRING在线估算是通过Cytoscape分析来预测蛋白质-蛋白质的功能和分子相互作用，以搜索和选择主基因。使用Cytoscape和STRING分析，我们展示了八个基因，RhoA,Smad3，Akt1，Cdk2，Rock1，Rock2，Mapk1和Mapk8作为与波形蛋白参与入侵的必需蛋白质-蛋白质相互作用。
