Abstract：
Background and Objectives: Extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT) type is the most common subtype of the ocular adnexal lymphoma. Despite its excellent prognosis, some patients experience partial remission or progressive disease. We aimed to evaluate clinicopathologic differences in the treatment responder group by comparing complete remission (CR) and non-complete remission (non-CR). Materials and Methods: This study retrospectively reviewed 48 patients who were diagnosed with ocular adnexal MALT lymphoma at Ulsan University Hospital between March 2002 and August 2018. Patients who were followed up for less than 6 months were excluded. Histologic and clinical features were analyzed. The patients were divided into two groups: CR and non-CR. Results: Among the 48 patients, 33 achieved CR and 15 achieved non-CR during the median follow-up period of 40.00 months (range, 7-109 months). In univariable analysis, more patients tend to undergo treatment in the CR group, and post-radiotherapy (post-RT) SUVmax, PET and serum lactate dehydrogenase (LDH) levels were higher in the non-CR group (p = 0.043, p = 0.016, and p = 0.042, respectively). In a multivariable analysis, only application of treatment, including radiotherapy or chemotherapy with immunotherapy, was related to CR (odd ratio 7.301, 95% confidence interval 1.273-41.862, p = 0.026). In subgroup analysis according to the site of involvement, none of the variables were significant except for the post-RT SUVmax of PET and level of serum LDH in the non-conjunctiva group (p = 0.026, and p = 0.037, respectively). Seven (14.6%) patients had a recurrence, and those with a recurring site other than the primary site had a higher Ki-67 labeling index, although it was not statistically significant (9.56% vs. 18.00%, p = 0.095). Conclusions: Although belonging to the early stages, the non-CR rate was high in patients with high serum LDH levels, and recurred patients had higher Ki-67. Thus, considering active treatment is recommended in this group of patients.
摘要：
背景与目的：结外边缘区淋巴瘤的粘膜相关淋巴组织（MALT）型是眼附属器淋巴瘤中最常见的亚型。尽管预后良好,一些患者经历部分缓解或进行性疾病。我们旨在通过比较完全缓解（CR）和非完全缓解（非CR）来评估治疗应答者组的临床病理差异。材料与方法：本研究回顾性分析了2002年3月至2018年8月在蔚山大学附属医院诊断为眼附属器MALT淋巴瘤的48例患者。随访少于6个月的患者被排除在外。分析组织学和临床特征。将患者分为两组：CR和非CR。结果:48例患者中,在40.00个月的中位随访期内，33个达到CR，15个达到非CR（范围，7-109个月）。在单变量分析中，CR组中更多的患者倾向于接受治疗，放疗后（放疗后）SUVmax，非CR组的PET和血清乳酸脱氢酶（LDH）水平较高（分别为p=0.043，p=0.016和p=0.042）。在多变量分析中，仅应用治疗，包括放疗或化疗和免疫疗法，与CR相关(奇数比7.301，95%置信区间1.273-41.862，p=0.026)。在根据参与部位的亚组分析中，在非结膜组中,除了PET的RT后SUVmax和血清LDH水平(分别为p=0.026和p=0.037)外,所有变量均无显著性。7例（14.6%）患者复发，那些具有除主要位点以外的复发位点的人具有更高的Ki-67标记指数，虽然没有统计学意义(9.56%vs.18.00%,p=0.095)。结论：虽然属于早期阶段，血清LDH水平高的患者的非CR率很高，复发患者的Ki-67较高。因此，考虑积极治疗，建议在这组患者。
