Abstract：
Carbapenems are an applicable subclass of β-lactam drugs in the antibiotic therapy of anaerobic infections, especially for poly-microbial cases, due to their broad antimicrobial spectrum on aerobic and anaerobic bacteria. Bacteroides fragilis is the most commonly recovered anaerobic bacteria in the clinical laboratories from mono- and poly-microbial infections. B. fragilis is relatively non-susceptible to different antibiotics, including β-lactams, tetracyclines, fluoroquinolones, and macrolides. Carbapenems are among the most effective drugs against B. fragilis strains with high-level resistance to different antibiotics. Increased antibiotic resistance of B. fragilis strains has been reported following the overuse of an antimicrobial agent. Earlier contact with carbapenems is linked with increased resistance to them that limits the options for treatment of B. fragilis caused infections, especially in cases caused by multidrug-resistant strains. Several molecular mechanisms of resistance to carbapenems have been described for different carbapenem-resistant bacteria. Understanding the mechanisms of resistance to antimicrobial agents is necessary for selecting alternative antimicrobial agents and the application of control strategies. In the present study, we reviewed the mechanisms contributing to resistance to carbapenems in B. fragilis strains.
摘要：
碳青霉烯类是β-内酰胺类药物在厌氧菌感染的抗生素治疗中的一个适用的亚类,特别是对于多微生物病例，由于它们对需氧和厌氧细菌具有广泛的抗菌谱。脆弱拟杆菌是临床实验室中从单微生物和多微生物感染中最常见的厌氧细菌。脆弱芽孢杆菌对不同的抗生素相对不敏感，包括β-内酰胺，四环素,氟喹诺酮类药物,和大环内酯类。碳青霉烯类是对抗脆弱芽孢杆菌菌株最有效的药物之一，对不同的抗生素具有高水平的耐药性。已经报道了在过度使用抗微生物剂后脆弱芽孢杆菌菌株的抗生素抗性增加。与碳青霉烯类抗生素的早期接触与对它们的耐药性增加有关，这限制了治疗脆弱芽孢杆菌引起的感染的选择。尤其是由多重耐药菌株引起的病例。已经针对不同的碳青霉烯类耐药细菌描述了对碳青霉烯类耐药的几种分子机制。了解抗微生物药物的耐药机制对于选择替代抗微生物药物和应用控制策略是必要的。在本研究中,我们综述了脆弱芽孢杆菌菌株对碳青霉烯类抗生素耐药的机制。
