Abstract：
BACKGROUND: The increased use of dental implants in oral rehabilitation has been followed by the development of new biomaterials as well as improvements in the performance of biomaterials already in use. This triggers the need for appropriate analytical approaches to assess the biological and, ultimately, clinical benefits of these approaches.
OBJECTIVE: To address the role of physical, chemical, mechanical, and biological characteristics in order to determine the critical parameters to improve biological responses and the long-term effectiveness of dental implant surfaces.
METHODS: Web of Science, MEDLINE and Lilacs databases were searched for the last 30 years in English, Spanish and Portuguese idioms.
RESULTS: Chemical composition, wettability, roughness, and topography of dental implant surfaces have all been linked to biological regulation in cell interactions, osseointegration, bone tissue and peri-implant mucosa preservation.
CONCLUSIONS: Techniques involving subtractive and additive methods, especially those involving laser treatment or embedding of bioactive nanoparticles, have demonstrated promising results. However, the literature is heterogeneous regarding study design and methodology, which limits comparisons between studies and the definition of the critical determinants of optimal cell response.
OBJECTIVE: To address the role of physical, chemical, mechanical, and biological characteristics in order to determine the critical parameters to improve biological responses and the long-term effectiveness of dental implant surfaces.
METHODS: Web of Science, MEDLINE and Lilacs databases were searched for the last 30 years in English, Spanish and Portuguese idioms.
RESULTS: Chemical composition, wettability, roughness, and topography of dental implant surfaces have all been linked to biological regulation in cell interactions, osseointegration, bone tissue and peri-implant mucosa preservation.
CONCLUSIONS: Techniques involving subtractive and additive methods, especially those involving laser treatment or embedding of bioactive nanoparticles, have demonstrated promising results. However, the literature is heterogeneous regarding study design and methodology, which limits comparisons between studies and the definition of the critical determinants of optimal cell response.
摘要：
背景：牙科植入物在口腔康复中的使用越来越多，随后开发新的生物材料以及已经使用的生物材料的性能得到改善。这引发了对适当的分析方法来评估生物和生物的需求，最终,这些方法的临床益处。
目的：为了解决身体，化学,机械,和生物学特性，以确定改善生物反应和牙种植体表面长期有效性的关键参数。
方法：WebofScience，在过去的30年中，搜索了MEDLINE和Lilacs数据库，西班牙语和葡萄牙语的成语。
结果：化学成分，润湿性,粗糙度,和牙种植体表面的形貌都与细胞相互作用中的生物调节有关，骨整合，骨组织和种植体周围粘膜保存。
结论：涉及减法和加法方法的技术，尤其是那些涉及激光治疗或生物活性纳米粒子的嵌入，已经证明了有希望的结果。然而,关于研究设计和方法论的文献是不同的，这限制了研究与最佳细胞反应的关键决定因素的定义之间的比较。
目的：为了解决身体，化学,机械,和生物学特性，以确定改善生物反应和牙种植体表面长期有效性的关键参数。
方法：WebofScience，在过去的30年中，搜索了MEDLINE和Lilacs数据库，西班牙语和葡萄牙语的成语。
结果：化学成分，润湿性,粗糙度,和牙种植体表面的形貌都与细胞相互作用中的生物调节有关，骨整合，骨组织和种植体周围粘膜保存。
结论：涉及减法和加法方法的技术，尤其是那些涉及激光治疗或生物活性纳米粒子的嵌入，已经证明了有希望的结果。然而,关于研究设计和方法论的文献是不同的，这限制了研究与最佳细胞反应的关键决定因素的定义之间的比较。
