In this review, we discuss how AYA-ALL is different from the pediatric ALL population, compare AYA-ALL with ALL in middle and older age adults, review the studies that have enrolled the AYA cohort, summarize risk-stratified and response-adapted approaches, describe the biological subtypes, and review the novel agents/approaches under evaluation.
AYA-ALL is a complex and challenging disease that needs multidisciplinary and focused care. Well-designed clinical trials that focus on this cohort are needed to further improve the outcomes.
在这篇评论中,我们讨论了AYA-ALL与儿科ALL人群的不同之处,将AYA-ALL与所有中老年人进行比较,回顾参加AYA队列的研究,总结风险分层和反应适应的方法,描述生物亚型,并回顾正在评估的新代理/方法。
AYA-ALL是一种复杂且具有挑战性的疾病,需要多学科和重点治疗。需要针对该队列进行精心设计的临床试验,以进一步改善结果。