CRISPR 介导的 MECOM 耗竭通过降低肺鳞状细胞癌中的癌症干细胞特性来延迟肿瘤生长。
关键词: CRISPR MECOM cancer stem cells lung squamous cell carcinoma
Mesh : Humans Carcinoma, Non-Small-Cell Lung / genetics therapy Carcinoma, Squamous Cell / genetics therapy Cell Line, Tumor Clustered Regularly Interspaced Short Palindromic Repeats Gene Expression Regulation, Neoplastic Lung Neoplasms / therapy drug therapy MDS1 and EVI1 Complex Locus Protein / genetics Neoplastic Stem Cells / metabolism Transcription Factors / genetics Animals
来 源:
DOI:10.1016/j.ymthe.2022.06.011
PDF(Pubmed)