Abstract：
The naked mole rat has unique biologic characteristics that include atypical inflammatory responses. Lipopolysaccharide induces inflammation which triggers brain centers controlling feeding, and behavior to result in \"sick animal behavior\". We characterized the bodyweight, locomotor, and other behavioral responses of this rodent to lipopolysaccharide administration. Lipopolysaccharide caused weight losses, which were not prevented by TAK 242. In the open field test, lipopolysaccharide did not depress locomotion, while urination, defecation, and activity freezing were rare. The animals exhibited walling but not rearing and fast backward movements that were unaffected by lipopolysaccharide. Failure to depress locomotion suggests either a unique immunity-brain crosstalk or motor responses/centers that tolerate depressive effects of inflammation. The absence of activity freezing and rarity of urination and defecation suggests that novel environments or lipopolysaccharide do not induce anxiety, or that anxiety is expressed differently in the animal. The absence of rearing could be due to the design of the animal\'s locomotor apparatus while fast backward movement could be a mechanism for quick escape from threats in the tunnels of their habitat. Our results elucidate the unique biology of this rodent, which elicits interest in the animal as a model for inflammatory research, although the findings require mechanistic corroborations.
摘要：
裸痣大鼠具有独特的生物学特征，包括非典型的炎症反应。脂多糖诱导炎症，引发大脑中枢控制进食，和行为导致“生病的动物行为”。我们表征了体重，运动，以及该啮齿动物对脂多糖给药的其他行为反应。脂多糖导致体重减轻，这是TAK242无法阻止的。在野外测试中，脂多糖不会抑制运动，在排尿的同时,排便,活动冻结很少见。动物表现出不受脂多糖影响的墙但没有饲养和快速向后运动。无法抑制运动表明独特的免疫-大脑串扰或耐受炎症抑制作用的运动反应/中枢。缺乏活动冷冻和罕见的排尿和排便表明，新的环境或脂多糖不会引起焦虑，或者焦虑在动物身上有不同的表现。缺乏饲养可能是由于动物运动装置的设计，而快速向后运动可能是一种快速逃离其栖息地隧道威胁的机制。我们的结果阐明了这种啮齿动物的独特生物学，这引起了人们对动物作为炎症研究模型的兴趣，尽管这些发现需要机械的佐证。
