PDF(Pubmed)
Abstract：
Limbic predominant age-related transactive response DNA binding protein 43 (TDP-43) encephalopathy neuropathological change (LATE-NC) is common in persons older than 80 years of age and is associated with cognitive decline and increased likelihood of dementia. The MRI signature of LATE-NC has not been fully determined. In this study, the association of LATE-NC with the transverse relaxation rate, R2, was investigated in a large number of community-based older adults. Cerebral hemispheres from 738 participants of the Rush Memory and Aging Project, Religious Orders Study, and Minority Aging Research Study, were imaged ex-vivo with multi-echo spin-echo MRI and underwent detailed neuropathologic examination. Voxel-wise analysis revealed a novel spatial pattern of lower R2 for higher LATE-NC stage, controlling for other neuropathologies and demographics. This pattern was consistent with the distribution of LATE-NC in gray matter, and also involved white matter providing temporo-temporal, fronto-temporal, and temporo-basal ganglia connectivity. Furthermore, analysis at different LATE-NC stages showed that R2 imaging may capture the general progression of LATE-NC, but only when TDP-43 inclusions extend beyond the amygdala.
摘要：
边缘占优势的年龄相关反应DNA结合蛋白43（TDP-43）脑病神经病理学改变（LATE-NC）常见于80岁以上的人，并与认知功能下降和痴呆的可能性增加有关。LATE-NC的MRI特征尚未完全确定。在这项研究中,LATE-NC与横向松弛率的关联，R2在大量社区老年人中进行了调查。Rush记忆和衰老项目738名参与者的大脑半球，宗教秩序研究，和少数民族老龄化研究，使用多回波自旋回波MRI进行离体成像，并进行了详细的神经病理学检查。体素分析揭示了较高LATE-NC阶段的较低R2的新空间格局，控制其他神经病理学和人口统计学。这种模式与灰质中LATE-NC的分布一致，还涉及白质提供时空，前颞叶,和颞基底神经节连接。此外，在不同LATE-NC阶段的分析表明，R2成像可以捕获LATE-NC的总体进展，但只有当TDP-43内含物延伸到杏仁核之外时。
