关键词: Cyanosis Intoxication Methemoglobinemia Methylene blue Nitrites

Mesh : Adult Cocaine / toxicity Cyanosis / chemically induced drug therapy Humans Hypoxia Male Methemoglobinemia / chemically induced diagnosis drug therapy Methylene Blue / therapeutic use Oxygen Smoking

来  源:   DOI:10.1186/s13256-022-03475-8

Abstract:
BACKGROUND: Methemoglobinemia is an excess of oxidized hemoglobin in the blood, affecting oxygen transportation. It is characterized by central cyanosis that does not respond to oxygen therapy. Prognosis is excellent when treated adequately and rapidly. We present a case report of a 38-year-old Caucasian man suffering from methemoglobinemia due to the use of poppers.
METHODS: A 38-year-old Caucasian man known as a smoker and addicted to cocaine was admitted to the emergency department with dyspnea, agitation, and central cyanosis that started approximately 3 hours before admission. The persistent hypoxia despite high-flow oxygen therapy and a history of poppers use helped to reveal a condition known as methemoglobinemia.
CONCLUSIONS: Our case highlighted a typical clinical presentation of methemoglobinemia. This possible life-threatening condition can occur after ingestion or inhalation of poppers, commonly sold in sex shops for recreational purposes. This can be easily confirmed by the methemoglobin level of the blood gases, provided the emergency physician considers this diagnosis. Rapid treatment with intravenous methylene blue is effective and leads to a favorable prognosis.
摘要:
背景:高铁血红蛋白血症是血液中过量的氧化血红蛋白,影响氧气运输。它的特征是对氧疗没有反应的中央紫癜。当充分和迅速治疗时,预后良好。我们提供了一例病例报告,一例38岁的高加索男子因使用罂粟碱而患有高铁血红蛋白血症。
方法:一名38岁的白人男子被称为吸烟者,对可卡因上瘾,因呼吸困难入院急诊,激动,和在入院前大约3小时开始的中央型紫癜。尽管进行了高流量氧气治疗,但持续的缺氧和使用poppers的历史有助于揭示一种称为高铁血红蛋白血症的疾病。
结论:我们的病例突出了高铁血红蛋白血症的典型临床表现。这种可能危及生命的情况可能发生在摄入或吸入爆裂剂后,通常在性用品商店出售,用于娱乐目的。这可以很容易地通过血气的高铁血红蛋白水平来证实,如果急诊医生考虑这个诊断。静脉注射亚甲蓝的快速治疗是有效的,并导致良好的预后。
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