PDF(Pubmed)
Abstract：
Background: Mass testing and adequate management are essential to terminate the spread of coronavirus disease 2019 (COVID-19). This testing is due to the possibility of unidentified cases, especially ones without COVID-19 related symptoms. This review aimed to examine the outcome of the existing studies on the ways of identifying COVID-19 cases, and determine the populations at risk, symptom and diagnostic test management of COVID-19. Methods: The articles reviewed were scientific publications on the PubMed, Science Direct, ProQuest, and Scopus databases. The keywords used to obtain the data were COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and case detection, case management or diagnostic test. We applied the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Population, Intervention, Control and Outcomes (PICO) approaches. Results: A total of 21 articles from 13 countries met the inclusion criteria and were further analyzed qualitatively. However, 62% of the articles used a rapid antibody test for screening rather than a rapid antigen test. According to the rapid antigen test, 51.3% were positive, with men aged above 50 years recording the highest number of cases. Furthermore, 57.1% of patients were symptomatic, while diagnostic tests\' sensitivity and specificity increased to 100% in 14 days after the onset. Conclusion s: Real-time polymerase chain reaction (RT-PCR) is recommended by the World Health Organization for detection of COVID-19. Suppose it is unavailable, the rapid antigen test is used as an alternative rather than the rapid antibody test. Diagnosis is expected to be confirmed using the PCR and serological assay to achieve an early diagnosis of COVID-19, according to disease progression, gradual rapid tests can be used, such as rapid antigen in an earlier week and antibody tests confirmed by RT-PCR and serological assay in the second week of COVID-19.
摘要：
背景：大规模检测和充分的管理对于终止2019年冠状病毒病（COVID-19）的传播至关重要。这种测试是由于身份不明的病例的可能性，尤其是没有COVID-19相关症状的患者。这篇综述旨在审查现有的COVID-19病例识别方法研究的结果，并确定处于危险中的人群，COVID-19的症状和诊断测试管理。方法：审查的文章是PubMed上的科学出版物，科学直接，ProQuest,和Scopus数据库。用于获取数据的关键词是COVID-19，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）和病例检测，病例管理或诊断测试。我们将首选报告项目用于系统评价和荟萃分析(PRISMA)和人口，干预,控制和结果（PICO）方法。结果:共有13个国家的21篇文章符合纳入标准,并进一步进行定性分析。然而,62％的文章使用快速抗体测试进行筛查，而不是快速抗原测试。根据快速抗原检测,51.3%为阳性,50岁以上的男性病例最多。此外，57.1％的患者有症状，而诊断测试的敏感性和特异性在发病后14天内增加到100%。结论:世界卫生组织推荐采用实时聚合酶链反应(RT-PCR)检测COVID-19。假设它不可用，快速抗原测试被用作替代而不是快速抗体测试。根据疾病进展，预计将通过PCR和血清学检测确认诊断，以实现COVID-19的早期诊断，可以使用逐步快速测试，如在COVID-19的早期一周进行快速抗原检测，并在第二周进行RT-PCR和血清学检测证实抗体检测。
