Abstract：
Periodontitis is a preventable and treatable multifactorial chronic inflammatory disease that can lead to irreversible periodontal destruction and tooth loss. Wnt signaling and its regulators play an important role in periodontal inflammation, destruction, regeneration, and reconstruction. This systematic review aimed at investigating the involvement of Wnt signaling agonists and antagonists in periodontitis and healthy subjects, before and after periodontal treatment. Electronic searches were carried out using MEDLINE/PubMed, EMBASE, and Cochrane Library databases in addition to hand searches. Studies having different designs assessing the levels of Wnt signaling antagonist and agonist levels in gingival crevicular fluid, serum, and tissue in patients diagnosed with periodontitis or gingivitis, compared with healthy individuals were included. In addition, studies compared these levels in periodontitis patients before and after non-surgical periodontal therapy were also eligible. Sixteen studies met the eligibility criteria. Sclerostin (SOST) has been mainly investigated in the literature (8 publications). Sclerostin (5 studies), Wnt-5a (2 studies), secreted frizzled-related protein 1 (SFRP1) (3 studies), and β-catenin (3 studies) show increased levels in periodontitis compared with periodontal health. Strong correlations between marker levels and periodontal clinical parameters were identified for SOST (5 studies), SFRP1 (2 studies), and β-catenin (2 studies). SOST (3 studies) and SFRP1 (1 study) levels significantly decrease following non-surgical periodontal treatment. The present systematic review demonstrated an association between Wnt signaling agonist and antagonist levels and periodontitis. Wnt agonists and antagonists may serve as valuable diagnostic and prognostic markers for periodontitis onset and progression. Further case-control and longitudinal studies should be conducted for different Wnt signaling agonists and antagonists.
摘要：
牙周炎是一种可预防和治疗的多因素慢性炎症性疾病，可导致不可逆的牙周破坏和牙齿脱落。Wnt信号及其调节因子在牙周炎症中发挥重要作用,破坏,再生,和重建。本系统综述旨在研究Wnt信号激动剂和拮抗剂在牙周炎和健康受试者中的参与。牙周治疗前后。使用MEDLINE/PubMed进行电子搜索，EMBASE,和Cochrane图书馆数据库除了手工搜索。具有不同设计的研究评估牙龈沟液中Wnt信号拮抗剂和激动剂水平，血清,和被诊断患有牙周炎或牙龈炎的患者的组织，与健康个体相比。此外,研究比较了牙周炎患者在非手术牙周治疗前后的这些水平也是合格的。16项研究符合资格标准。硬化蛋白（SOST）主要在文献（8种出版物）中进行了研究。硬化蛋白（5项研究），Wnt-5a（2项研究），分泌型卷曲相关蛋白1（SFRP1）（3项研究），和β-连环蛋白（3项研究）显示，与牙周健康相比，牙周炎中的水平增加。SOST（5项研究）确定了标记物水平与牙周临床参数之间的强相关性，SFRP1（2项研究），和β-连环蛋白（2项研究）。牙周非手术治疗后，SOST（3项研究）和SFRP1（1项研究）水平显着降低。本系统综述证明了Wnt信号激动剂和拮抗剂水平与牙周炎之间的关联。Wnt激动剂和拮抗剂可作为牙周炎发作和进展的有价值的诊断和预后标志物。应该对不同的Wnt信号激动剂和拮抗剂进行进一步的病例对照和纵向研究。
