Abstract：
Cancer is recognized as the leading cause of death worldwide. The hippo signaling pathway regulates organ size by balancing cell proliferation and cell death; hence dysregulation of the hippo pathway promotes cancer‑like conditions. miRNAs are a type of non‑coding RNA that have been shown to regulate gene expression. miRNA levels are altered in various classes of cancer. Researchers have also uncovered a crosslinking between miRNAs and the hippo pathway, which has been linked to cancer. The components of the hippo pathway regulate miRNA synthesis, and various miRNAs regulate the components of the hippo pathway both positively and negatively, which can lead to cancer‑like conditions. In the present review article, the mechanism behind the hippo signaling pathway and miRNAs biogenesis and crosslinks between miRNAs and the hippo pathway, which result in cancer, shall be discussed. Furthermore, the article will cover miRNA‑related therapeutics and provide an overview of the development of resistance to anticancer drugs. Understanding the underlying processes would improve the chances of developing effective cancer treatment therapies.
摘要：
癌症是全球公认的主要死亡原因。Hippo信号通路通过平衡细胞增殖和细胞死亡来调节器官大小；因此，Hippo通路的失调会促进癌症样状况。miRNA是一种非编码RNA，已被证明可以调节基因表达。miRNA水平在各种类型的癌症中改变。研究人员还发现了miRNAs和河马通路之间的交联，这与癌症有关。Hippo通路的组分调节miRNA的合成，各种miRNAs正向和负向调节Hippo途径的组成部分，会导致类似癌症的情况。在本评论文章中，Hippo信号通路和miRNAs生物发生背后的机制以及miRNAs和Hippo通路之间的交联，导致癌症，将讨论。此外，这篇文章将涵盖miRNA相关的治疗方法，并概述抗癌药物的耐药性发展。了解潜在的过程将提高开发有效的癌症治疗疗法的机会。
