Abstract：
The role of human oncoviruses in melanoma has been poorly investigated. The aim of this study was to investigate the association between oncoviruses and melanomas searching for human papillomavirus (HPV), Epstein Barr virus (EBV), and human herpesvirus 8DNA in melanoma specimens. Formalin-fixed and paraffin-embedded tissue specimens of cutaneous, mucosal, and ocular melanomas (OM) were selected from the Pathology Departments of the Galliera Hospital (Genoa) and the University Hospitals of Turin and Cagliari. Cutaneous and mucosal nevi have been collected as controls. The oncoviruses search has been performed with different polymerase chain reaction reagent kits. Fifty-four melanomas (25 mucosal, 12 ocular, and 17 cutaneous) and 26 nevi (15 cutaneous and 11 mucosal) specimens were selected. The detection rate for one of the investigated oncoviruses was 17% in mucosal, 20% in ocular, and 0% in cutaneous melanomas (CMs). Despite the differences between groups seeming remarkable, there was no statistical significance (p > 0.5). Our data do not support a primary role of oncoviruses in melanoma carcinogenesis; however, the finding of HPV and EBV DNA in a considerable fraction of mucosal and OMs suggests that these viruses may act as cofactors in the development of extra-CMs.
摘要：
人类肿瘤病毒在黑色素瘤中的作用研究甚少。这项研究的目的是研究癌病毒和黑色素瘤之间的关联，寻找人乳头瘤病毒（HPV），EB病毒(EBV),和黑色素瘤标本中的人类疱疹病毒8DNA。福尔马林固定和石蜡包埋的皮肤组织标本，粘膜，和眼部黑色素瘤（OM）选自Galliera医院（热那亚）和都灵大学医院和卡利亚里大学医院的病理科。已收集皮肤和粘膜痣作为对照。已使用不同的聚合酶链反应试剂盒进行了肿瘤病毒搜索。54个黑素瘤（25个粘膜，12眼，和17个皮肤）和26个痣（15个皮肤和11个粘膜）标本。其中一种被调查的肿瘤病毒在粘膜中的检出率为17％，20%的眼,皮肤黑色素瘤（CMs）为0％。尽管群体之间的差异似乎很明显，无统计学意义(p>0.5)。我们的数据不支持肿瘤病毒在黑色素瘤癌变中的主要作用；然而，
