UNASSIGNED: Consecutive patients (N = 138, mean [standard deviation, SD] age 29.3 [12.9] years; 66 men) with BCS, treated with medical therapy alone including anticoagulation, with minimum follow-up of 12 months were included. Initial response was classified as complete (CR), partial (PR) or nonresponse (NR) and on follow-up as loss of response (LoR) or maintenance of response (MoR). The association of baseline, clinical and biochemical parameters with different responses was evaluated.
UNASSIGNED: Seventy-six patients (55.1%) had CR, 26 (18.8%) had PR and 36 (26.1%) had NR. None with PR or NR had CR later. At a median follow-up of 40 (range 12-174) months, LoR was more common in PR group than in CR group (12 [46.2%] vs 18 [23.7%], P = 0.03). LoR was associated with presence of ascites (odds ratio [OR] 1.5; 95% confidence interval [CI] 0.06-0.71), gastrointestinal bleed (OR 1.33; 95% CI 0.09-0.82) or jaundice (OR 1.01; 95% CI 0.11-0.97) at baseline and duration of follow-up (OR 0.018; 95% CI 1.006-1.030). Mortality was higher in NR (28 [77.8%]) compared with CR (15 [19.7%], P = 0.001) and PR (8 [30.8%], P = 0.001). On binary logistic regression analysis, presence of ascites at baseline was associated with LoR (OR 0.303 [0.098-0.931]).
UNASSIGNED: Patients with initial CR have better survival than nonresponders. One-third had LoR on follow-up. The presence of ascites at baseline is associated with LoR.
■连续患者(N=138,平均值[标准差,SD]年龄29.3[12.9]岁;66名男性)患有BCS,仅接受药物治疗,包括抗凝治疗,纳入最少随访12个月.初始反应被分类为完全(CR),部分(PR)或无应答(NR),并作为应答丧失(LoR)或应答维持(MoR)进行随访。基线的关联,评估了具有不同反应的临床和生化参数.
■76例患者(55.1%)有CR,26例(18.8%)有PR,36例(26.1%)有NR。具有PR或NR的人后来都没有CR。在中位随访40(范围12-174)个月时,LoR在PR组比CR组更常见(12[46.2%]vs18[23.7%],P=0.03)。LoR与腹水的存在相关(比值比[OR]1.5;95%置信区间[CI]0.06-0.71),基线和随访期间的胃肠道出血(OR1.33;95%CI0.09-0.82)或黄疸(OR1.01;95%CI0.11-0.97)(OR0.018;95%CI1.006-1.030)。NR(28[77.8%])死亡率高于CR(15[19.7%],P=0.001)和PR(8[30.8%],P=0.001)。在二元逻辑回归分析中,基线时腹水的存在与LoR相关(OR0.303[0.098-0.931]).
■初始CR患者的生存率优于无反应者。三分之一的人在后续行动中有LoR。基线时腹水的存在与LoR相关。