METHODS: After systematic literature search on Medline, EMBASE, Web of Science and the Cochrane Library, a qualitative meta-synthesis and quantitative meta-analysis were conducted. Meta-analysis was carried out on aggregated AUC data for different perfusion metrics.
RESULTS: Of 680 papers, twelve were included for the qualitative meta-synthesis, totaling 1384 patients. It was observed that CBV, ktrans, Ve and Vp values were, in general, significantly higher in IDH wildtype compared to IDH mutated glioma. Meta-analysis comprising of five papers (totaling 316 patients) showed that the AUC of CBV, ktrans, Ve and Vp were 0.85 (95%-CI 0.75-0.93), 0.81 (95%-CI 0.74-0.89), 0.84 (95%-CI 0.71-0.97) and 0.76 (95%-CI 0.61-0.90), respectively. No conclusive data on the prediction of 1p/19q integrity was available from these studies.
CONCLUSIONS: Future research should aim to predict 1p/19q integrity based on perfusion MRI data. Additionally, correlations with other clinically relevant outcomes should be further investigated, including patient stratification for treatment and overall survival.
方法:在Medline上进行系统的文献检索后,EMBASE,WebofScience和Cochrane图书馆,进行了定性荟萃综合和定量荟萃分析.对不同灌注指标的汇总AUC数据进行Meta分析。
结果:在680篇论文中,包括12个用于定性元合成,共1384名患者。据观察,CBV,ktrans,Ve和Vp值为,总的来说,与IDH突变的神经胶质瘤相比,IDH野生型明显更高。包括五篇论文(共316例患者)的荟萃分析显示,CBV的AUC,ktrans,Ve和Vp为0.85(95%-CI0.75-0.93),0.81(95%-CI0.74-0.89),0.84(95%-CI0.71-0.97)和0.76(95%-CI0.61-0.90),分别。从这些研究中没有关于1p/19q完整性预测的结论性数据。
结论:未来的研究应旨在基于灌注MRI数据预测1p/19q完整性。此外,与其他临床相关结果的相关性应进一步研究,包括患者分层治疗和总生存期。