Abstract：
BACKGROUND: Molecular characterization plays a crucial role in glioma classification which impacts treatment strategy and patient outcome. Dynamic susceptibility contrast (DSC) and dynamic contrast enhanced (DCE) perfusion imaging have been suggested as methods to help characterize glioma in a non-invasive fashion. This study set out to review and meta-analyze the evidence on the accuracy of DSC and/or DCE perfusion MRI in predicting IDH genotype and 1p/19q integrity status.
METHODS: After systematic literature search on Medline, EMBASE, Web of Science and the Cochrane Library, a qualitative meta-synthesis and quantitative meta-analysis were conducted. Meta-analysis was carried out on aggregated AUC data for different perfusion metrics.
RESULTS: Of 680 papers, twelve were included for the qualitative meta-synthesis, totaling 1384 patients. It was observed that CBV, ktrans, Ve and Vp values were, in general, significantly higher in IDH wildtype compared to IDH mutated glioma. Meta-analysis comprising of five papers (totaling 316 patients) showed that the AUC of CBV, ktrans, Ve and Vp were 0.85 (95%-CI 0.75-0.93), 0.81 (95%-CI 0.74-0.89), 0.84 (95%-CI 0.71-0.97) and 0.76 (95%-CI 0.61-0.90), respectively. No conclusive data on the prediction of 1p/19q integrity was available from these studies.
CONCLUSIONS: Future research should aim to predict 1p/19q integrity based on perfusion MRI data. Additionally, correlations with other clinically relevant outcomes should be further investigated, including patient stratification for treatment and overall survival.
METHODS: After systematic literature search on Medline, EMBASE, Web of Science and the Cochrane Library, a qualitative meta-synthesis and quantitative meta-analysis were conducted. Meta-analysis was carried out on aggregated AUC data for different perfusion metrics.
RESULTS: Of 680 papers, twelve were included for the qualitative meta-synthesis, totaling 1384 patients. It was observed that CBV, ktrans, Ve and Vp values were, in general, significantly higher in IDH wildtype compared to IDH mutated glioma. Meta-analysis comprising of five papers (totaling 316 patients) showed that the AUC of CBV, ktrans, Ve and Vp were 0.85 (95%-CI 0.75-0.93), 0.81 (95%-CI 0.74-0.89), 0.84 (95%-CI 0.71-0.97) and 0.76 (95%-CI 0.61-0.90), respectively. No conclusive data on the prediction of 1p/19q integrity was available from these studies.
CONCLUSIONS: Future research should aim to predict 1p/19q integrity based on perfusion MRI data. Additionally, correlations with other clinically relevant outcomes should be further investigated, including patient stratification for treatment and overall survival.
摘要：
背景：分子表征在影响治疗策略和患者预后的神经胶质瘤分类中起着至关重要的作用。已提出动态敏感性对比（DSC）和动态对比增强（DCE）灌注成像作为帮助以非侵入性方式表征神经胶质瘤的方法。本研究旨在回顾和荟萃分析DSC和/或DCE灌注MRI预测IDH基因型和1p/19q完整性状态的准确性的证据。
方法：在Medline上进行系统的文献检索后，EMBASE,WebofScience和Cochrane图书馆,进行了定性荟萃综合和定量荟萃分析.对不同灌注指标的汇总AUC数据进行Meta分析。
结果：在680篇论文中，包括12个用于定性元合成，共1384名患者。据观察，CBV，ktrans,Ve和Vp值为，总的来说,与IDH突变的神经胶质瘤相比，IDH野生型明显更高。包括五篇论文(共316例患者)的荟萃分析显示，CBV的AUC，ktrans,Ve和Vp为0.85(95%-CI0.75-0.93)，0.81（95%-CI0.74-0.89），0.84（95%-CI0.71-0.97）和0.76（95%-CI0.61-0.90），分别。从这些研究中没有关于1p/19q完整性预测的结论性数据。
结论：未来的研究应旨在基于灌注MRI数据预测1p/19q完整性。此外,与其他临床相关结果的相关性应进一步研究，包括患者分层治疗和总生存期。
方法：在Medline上进行系统的文献检索后，EMBASE,WebofScience和Cochrane图书馆,进行了定性荟萃综合和定量荟萃分析.对不同灌注指标的汇总AUC数据进行Meta分析。
结果：在680篇论文中，包括12个用于定性元合成，共1384名患者。据观察，CBV，ktrans,Ve和Vp值为，总的来说,与IDH突变的神经胶质瘤相比，IDH野生型明显更高。包括五篇论文(共316例患者)的荟萃分析显示，CBV的AUC，ktrans,Ve和Vp为0.85(95%-CI0.75-0.93)，0.81（95%-CI0.74-0.89），0.84（95%-CI0.71-0.97）和0.76（95%-CI0.61-0.90），分别。从这些研究中没有关于1p/19q完整性预测的结论性数据。
结论：未来的研究应旨在基于灌注MRI数据预测1p/19q完整性。此外,与其他临床相关结果的相关性应进一步研究，包括患者分层治疗和总生存期。
