METHODS: Studies relevant with the impact of MAFLD severity on the risk of colorectal neoplasms published before 24th April 2022 were screened. The pooled odds ratio (OR) with corresponding 95% confidence intervals (95% CI) was obtained using standard and cumulative meta-analyses. Subgroup, meta-regression, and sensitivity analyses were carried out to identify heterogeneity.
RESULTS: Fourteen studies with data from 37,824 MAFLD patients were included. The prevalence of colorectal neoplasms escalated with the progression of MAFLD compared to simple steatosis (OR = 1.93; 95% CI = 1.42-2.62). The magnitude and direction of the effect on these outcomes remained largely constant over time. Even after limiting the meta-analysis to 8 studies with available adjusted OR (aOR), the findings still suggested that MAFLD severity was positively related to colorectal neoplasms (aOR = 3.03; 95% CI = 2.02-4.53). Severe MAFLD was more likely to cause left colon tumors (OR = 3.86, 95% CI = 2.16-6.91) than right colon neoplasms (OR = 1.94, 95% CI = 1.15-3.28).
CONCLUSIONS: The severity of MAFLD was independently related to colorectal neoplasms and severe MAFLD was more likely to cause left colon tumors.
方法:筛选了2022年4月24日前发表的与MAFLD严重程度对结直肠肿瘤风险影响相关的研究。使用标准和累积荟萃分析获得合并比值比(OR)和相应的95%置信区间(95%CI)。子组,元回归,并进行了敏感性分析以确定异质性。
结果:纳入了来自37,824例MAFLD患者的14项研究。与单纯脂肪变性相比,结直肠肿瘤的患病率随着MAFLD的进展而上升(OR=1.93;95%CI=1.42-2.62)。随着时间的推移,对这些结果的影响的大小和方向在很大程度上保持不变。即使将荟萃分析限制为8项具有可用调整OR(aOR)的研究,结果仍提示MAFLD严重程度与结直肠肿瘤呈正相关(aOR=3.03;95%CI=2.02~4.53).重度MAFLD比右半结肠肿瘤(OR=1.94,95%CI=1.15-3.28)更容易引起左半结肠肿瘤(OR=3.86,95%CI=2.16-6.91)。
结论:MAFLD的严重程度与结直肠肿瘤独立相关,严重的MAFLD更容易引起左结肠肿瘤。