Abstract：
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms reaction (DRESS) syndrome is a serious, potentially life-threatening drug side effect associated with more and more drugs. However, antipsychotics have rarely been involved in such condition.
METHODS: We report here a suspected case of chlorpromazine induced DRESS syndrome in a 33-year-old woman with a history of allergic rhinitis and bipolar disorder who has reported an unexplored generalized skin eruption after taking chlorpromazine 10 years before. Only 24 hours after starting the therapy, the patient developed erythematous skin eruption on her limbs and her trunk with biological abnormalities, including liver enzyme elevation and eosinophilia. Skin eruption disappeared spontaneously within 3 days after therapy discontinuation and subsequently, biological abnormalities regressed. Patch tests were performed and were positive for chlorpromazine. At same time, we performed a literature review of the DRESS syndrome induced by antipsychotics. No patch tests were performed for those cases.
CONCLUSIONS: Clinicians should be aware of such clinical features after starting patients on antipsychotics to withdraw the culprit drug as early as possible and avoid further complications.
METHODS: We report here a suspected case of chlorpromazine induced DRESS syndrome in a 33-year-old woman with a history of allergic rhinitis and bipolar disorder who has reported an unexplored generalized skin eruption after taking chlorpromazine 10 years before. Only 24 hours after starting the therapy, the patient developed erythematous skin eruption on her limbs and her trunk with biological abnormalities, including liver enzyme elevation and eosinophilia. Skin eruption disappeared spontaneously within 3 days after therapy discontinuation and subsequently, biological abnormalities regressed. Patch tests were performed and were positive for chlorpromazine. At same time, we performed a literature review of the DRESS syndrome induced by antipsychotics. No patch tests were performed for those cases.
CONCLUSIONS: Clinicians should be aware of such clinical features after starting patients on antipsychotics to withdraw the culprit drug as early as possible and avoid further complications.
摘要：
背景：伴嗜酸性粒细胞增多和全身症状反应（DRESS）综合征的药物反应是一种严重的潜在威胁生命的药物副作用，越来越多的药物与这种副作用有关。然而,抗精神病药物很少参与这种情况。
方法：我们在此报告一例疑似氯丙嗪诱发DRESS综合征的病例，该病例有过敏性鼻炎和双相情感障碍病史的33岁女性，10年前服用氯丙嗪后报告了未发现的全身性皮肤疹。开始治疗后仅24小时，患者的四肢和躯干出现红斑性皮疹，并伴有生物学异常，包括肝酶升高和嗜酸性粒细胞增多。皮肤爆发在治疗停止后3天内自发消失，随后，生物异常消退。进行了斑贴试验，氯丙嗪呈阳性。同时,我们对抗精神病药物诱发的DRESS综合征进行了文献综述.对于这些情况没有进行补丁测试。
结论：在患者开始服用抗精神病药物后，临床医生应了解这些临床特征，以便尽早撤回罪魁祸首药物，并避免进一步的并发症。
方法：我们在此报告一例疑似氯丙嗪诱发DRESS综合征的病例，该病例有过敏性鼻炎和双相情感障碍病史的33岁女性，10年前服用氯丙嗪后报告了未发现的全身性皮肤疹。开始治疗后仅24小时，患者的四肢和躯干出现红斑性皮疹，并伴有生物学异常，包括肝酶升高和嗜酸性粒细胞增多。皮肤爆发在治疗停止后3天内自发消失，随后，生物异常消退。进行了斑贴试验，氯丙嗪呈阳性。同时,我们对抗精神病药物诱发的DRESS综合征进行了文献综述.对于这些情况没有进行补丁测试。
结论：在患者开始服用抗精神病药物后，临床医生应了解这些临床特征，以便尽早撤回罪魁祸首药物，并避免进一步的并发症。
