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Abstract：
UNASSIGNED: Neurocognitive deficits are well-documented in patients of schizophrenia and their first-degree relatives (FDRs). Metacognitive awareness of these deficits, called neurocognitive insight (NI), has been found to be poor in schizophrenia patients but has not been assessed in their FDRs. This study evaluated NI and its relationship with objective cognitive performance, a history of psychotic experiences (PEs), and social functioning in unaffected FDRs.
UNASSIGNED: This cross-sectional study was conducted at the outpatient department of a tertiary care teaching hospital. A total of 100 FDRs were assessed for PEs and evaluated for subjective cognitive complaints (SCC), objective cognitive performance, and social functioning using the Subjective Scale to Investigate Cognition in Schizophrenia, neurocognitive tests from the National Institute of Mental Health and Neurosciences battery, and SCARF Social Functioning Index, respectively.
UNASSIGNED: Compared to normative data, episodic memory was the most commonly impaired domain (up to 72% of participants), followed by working memory, attention, and executive function. There was no correlation between SCC and neuropsychological test scores in the corresponding cognitive domains, implying poor NI. 15% of participants had a lifetime history of PEs. This group had significantly higher SCC as compared to those without PEs (U = 0.366, P = 0.009, r = 0.26). A regression analysis showed that the FDRs\' social functioning reduced by 0.178 units for each unit increase in SCC [F (1,98) = 5.198, P = 0.025].
UNASSIGNED: Similar to schizophrenia patients, FDRs also have poor NI. The severity and progression of SCC could be explored as a possible marker for screening and monitoring FDRs at an ultrahigh risk for psychosis. Importantly, even in unaffected FDRs, SCC could affect socio-occupational functioning and need further research.
UNASSIGNED: This cross-sectional study was conducted at the outpatient department of a tertiary care teaching hospital. A total of 100 FDRs were assessed for PEs and evaluated for subjective cognitive complaints (SCC), objective cognitive performance, and social functioning using the Subjective Scale to Investigate Cognition in Schizophrenia, neurocognitive tests from the National Institute of Mental Health and Neurosciences battery, and SCARF Social Functioning Index, respectively.
UNASSIGNED: Compared to normative data, episodic memory was the most commonly impaired domain (up to 72% of participants), followed by working memory, attention, and executive function. There was no correlation between SCC and neuropsychological test scores in the corresponding cognitive domains, implying poor NI. 15% of participants had a lifetime history of PEs. This group had significantly higher SCC as compared to those without PEs (U = 0.366, P = 0.009, r = 0.26). A regression analysis showed that the FDRs\' social functioning reduced by 0.178 units for each unit increase in SCC [F (1,98) = 5.198, P = 0.025].
UNASSIGNED: Similar to schizophrenia patients, FDRs also have poor NI. The severity and progression of SCC could be explored as a possible marker for screening and monitoring FDRs at an ultrahigh risk for psychosis. Importantly, even in unaffected FDRs, SCC could affect socio-occupational functioning and need further research.
摘要：
■神经认知缺陷在精神分裂症患者及其一级亲属（FDRs）中有很好的记录。对这些缺陷的元认知意识，称为神经认知洞察力(NI)，已发现精神分裂症患者较差，但尚未在其FDR中进行评估。本研究评估了NI及其与客观认知表现的关系，精神病经历史（PE），以及未受影响的FDR的社会功能。
■这项横断面研究是在三级护理教学医院的门诊部进行的。总共对100个FDR进行了PE评估，并对主观认知投诉(SCC)进行了评估。客观认知表现，使用主观量表调查精神分裂症的认知和社会功能，国家心理健康和神经科学研究所的神经认知测试，和SCARF社会功能指数，分别。
■与规范数据相比，情景记忆是最常见的受损领域(高达72%的参与者)，其次是工作记忆，注意,和执行功能。在相应的认知领域，SCC与神经心理学测验得分之间没有相关性，暗示可怜的NI。15%的参与者有终身PE史。与没有PE的患者相比，该组的SCC明显更高（U=0.366，P=0.009，r=0.26）。回归分析表明，SCC每增加一个单位，FDRs的社会功能就减少0.178个单位[F（1,98）=5.198，P=0.025]。
■与精神分裂症患者相似，FDR的NI也很差。可以探索SCC的严重程度和进展，作为筛查和监测精神病超高风险FDRs的可能标志物。重要的是,即使在不受影响的FDR中，SCC可能会影响社会职业功能，需要进一步研究。
■这项横断面研究是在三级护理教学医院的门诊部进行的。总共对100个FDR进行了PE评估，并对主观认知投诉(SCC)进行了评估。客观认知表现，使用主观量表调查精神分裂症的认知和社会功能，国家心理健康和神经科学研究所的神经认知测试，和SCARF社会功能指数，分别。
■与规范数据相比，情景记忆是最常见的受损领域(高达72%的参与者)，其次是工作记忆，注意,和执行功能。在相应的认知领域，SCC与神经心理学测验得分之间没有相关性，暗示可怜的NI。15%的参与者有终身PE史。与没有PE的患者相比，该组的SCC明显更高（U=0.366，P=0.009，r=0.26）。回归分析表明，SCC每增加一个单位，FDRs的社会功能就减少0.178个单位[F（1,98）=5.198，P=0.025]。
■与精神分裂症患者相似，FDR的NI也很差。可以探索SCC的严重程度和进展，作为筛查和监测精神病超高风险FDRs的可能标志物。重要的是,即使在不受影响的FDR中，SCC可能会影响社会职业功能，需要进一步研究。
