Abstract:
Thyroid storm (TS) is a rare and life-threatening medical emergency, most commonly caused by Graves\' disease (GD). GD can be induced by immune reconstitution therapy (IRT) such as alemtuzumab (ALZ), a humanized monoclonal antibody against CD52, which is shown to be effective in the treatment of relapsing-remitting multiple sclerosis (RRMS). Here, we present a rare case of TS developing in a 39-year-old female with ALZ-induced GD, managed with antithyroid medication followed by thyroidectomy. There is some evidence that ALZ-induced GD may behave less aggressively than conventional GD. However, physicians should be aware that severe thyrotoxicosis and thyroid storm can happen, which requires prompt recognition and aggressive therapy.
摘要:
甲状腺风暴(TS)是一种罕见且危及生命的医疗紧急情况,最常见的是由Graves病(GD)引起的。GD可以通过免疫重建疗法(IRT)如阿仑单抗(ALZ)诱导,一种针对CD52的人源化单克隆抗体,该抗体被证明可有效治疗复发缓解型多发性硬化症(RRMS)。这里,我们提出了一个罕见的TS发展在一个39岁的女性与ALZ诱导GD,采用抗甲状腺药物治疗,然后进行甲状腺切除术。有一些证据表明,ALZ诱导的GD可能比常规GD表现得更少。然而,医生应该意识到严重的甲状腺毒症和甲状腺风暴可能发生,这需要及时的识别和积极的治疗。