PDF(Pubmed)
Abstract：
Thyroid storm (TS) is a rare and life-threatening medical emergency, most commonly caused by Graves\' disease (GD). GD can be induced by immune reconstitution therapy (IRT) such as alemtuzumab (ALZ), a humanized monoclonal antibody against CD52, which is shown to be effective in the treatment of relapsing-remitting multiple sclerosis (RRMS). Here, we present a rare case of TS developing in a 39-year-old female with ALZ-induced GD, managed with antithyroid medication followed by thyroidectomy. There is some evidence that ALZ-induced GD may behave less aggressively than conventional GD. However, physicians should be aware that severe thyrotoxicosis and thyroid storm can happen, which requires prompt recognition and aggressive therapy.
摘要：
甲状腺风暴（TS）是一种罕见且危及生命的医疗紧急情况，最常见的是由Graves病（GD）引起的。GD可以通过免疫重建疗法（IRT）如阿仑单抗（ALZ）诱导，一种针对CD52的人源化单克隆抗体，该抗体被证明可有效治疗复发缓解型多发性硬化症（RRMS）。这里,我们提出了一个罕见的TS发展在一个39岁的女性与ALZ诱导GD，采用抗甲状腺药物治疗，然后进行甲状腺切除术。有一些证据表明，ALZ诱导的GD可能比常规GD表现得更少。然而,医生应该意识到严重的甲状腺毒症和甲状腺风暴可能发生，这需要及时的识别和积极的治疗。
