UNASSIGNED: Nutritional status was assessed using a nutritional risk index (NRI) developed for patients undergoing MHD. This retrospective cross-sectional study included 315 MHD patients (199 males, 116 females), who were divided into low-risk (score 0-7) and medium-/high-risk (score 8-13) groups. Sarcopenia and severe sarcopenia, along with low muscle mass, low muscle strength, and low physical performance were defined using the Asian Working Group for Sarcopenia 2019 criteria.
UNASSIGNED: The median NRI score was 5.0, while the prevalence of medium-/high-risk cases among the patients was 31.1%. Additionally, the rates of those with low muscle mass, low muscle strength, and low physical performance were 55.9, 60.6, and 31.4%, respectively, while those of sarcopenia and severe sarcopenia were 44.1 and 20.0%, respectively. Multivariable logistic regression analyses revealed a significant (P < 0.001) association of NRI score with sarcopenia [odds ratio (OR) 1.255, 95% confidence interval (CI) 1.143-1.377] and severe sarcopenia (OR 1.257, 95% CI 1.122-1.407), as well as low muscle mass (OR 1.260, 95% CI 1.157-1.374), low muscle strength (OR 1.310, 95% CI 1.178-1.457), and low physical performance (OR 1.216, 95% CI 1.104-1.339). Furthermore, medium-/high-risk status showed a significant (P < 0.05) association with sarcopenia (OR 2.960, 95% CI 1.623-5.401) and severe sarcopenia (OR 2.241, 95% CI 1.151-4.362), as well as low muscle mass (OR 2.141, 95% CI 1.219-3.760), low muscle strength (OR 7.665, 95% CI 3.438-17.091), and low physical performance (OR 2.570, 95% CI 1.401-4.716).
UNASSIGNED: These results suggest that malnutrition contributes to sarcopenia/severe sarcopenia in MHD patients by reducing muscle mass and strength, and physical performance.
使用为接受MHD的患者制定的营养风险指数(NRI)评估营养状况。这项回顾性横断面研究包括315名MHD患者(199名男性,116名女性),将其分为低风险(0-7分)和中/高风险(8-13分)组。少肌症和重度少肌症,伴随着低肌肉质量,肌肉力量低,和低体能表现使用亚洲工作组2019年肌肉减少症标准定义。
■NRI评分中位数为5.0,而患者中/高危病例的患病率为31.1%。此外,那些肌肉质量低的人的比率,肌肉力量低,低物理性能分别为55.9、60.6和31.4%,分别,而肌肉减少症和严重肌肉减少症分别为44.1%和20.0%,分别。多变量逻辑回归分析显示,NRI评分与肌肉减少症[比值比(OR)1.255,95%置信区间(CI)1.143-1.377]和严重肌肉减少症(OR1.257,95%CI1.122-1.407)之间存在显着关联(P<0.001)。以及低肌肉质量(OR1.260,95%CI1.157-1.374),低肌肉力量(OR1.310,95%CI1.178-1.457),和低物理性能(OR1.216,95%CI1.104-1.339)。此外,中/高危状态显示与肌肉减少症(OR2.960,95%CI1.523-5.401)和严重肌肉减少症(OR2.241,95%CI1.151-4.362)存在显着相关性(P<0.05),以及低肌肉质量(OR2.141,95%CI1.219-3.760),低肌肉力量(OR7.665,95%CI3.438-17.091),和低物理性能(OR2.570,95%CI1.401-4.716)。
■这些结果表明,营养不良通过减少肌肉质量和力量而导致MHD患者的肌肉减少/严重肌肉减少,和物理性能。