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Abstract：
UNASSIGNED: Malnutrition and sarcopenia are frequently observed in patients undergoing maintenance hemodialysis (MHD). To elucidate whether malnutrition is associated with sarcopenia in those cases, the relationship of nutritional status with sarcopenia was investigated.
UNASSIGNED: Nutritional status was assessed using a nutritional risk index (NRI) developed for patients undergoing MHD. This retrospective cross-sectional study included 315 MHD patients (199 males, 116 females), who were divided into low-risk (score 0-7) and medium-/high-risk (score 8-13) groups. Sarcopenia and severe sarcopenia, along with low muscle mass, low muscle strength, and low physical performance were defined using the Asian Working Group for Sarcopenia 2019 criteria.
UNASSIGNED: The median NRI score was 5.0, while the prevalence of medium-/high-risk cases among the patients was 31.1%. Additionally, the rates of those with low muscle mass, low muscle strength, and low physical performance were 55.9, 60.6, and 31.4%, respectively, while those of sarcopenia and severe sarcopenia were 44.1 and 20.0%, respectively. Multivariable logistic regression analyses revealed a significant (P < 0.001) association of NRI score with sarcopenia [odds ratio (OR) 1.255, 95% confidence interval (CI) 1.143-1.377] and severe sarcopenia (OR 1.257, 95% CI 1.122-1.407), as well as low muscle mass (OR 1.260, 95% CI 1.157-1.374), low muscle strength (OR 1.310, 95% CI 1.178-1.457), and low physical performance (OR 1.216, 95% CI 1.104-1.339). Furthermore, medium-/high-risk status showed a significant (P < 0.05) association with sarcopenia (OR 2.960, 95% CI 1.623-5.401) and severe sarcopenia (OR 2.241, 95% CI 1.151-4.362), as well as low muscle mass (OR 2.141, 95% CI 1.219-3.760), low muscle strength (OR 7.665, 95% CI 3.438-17.091), and low physical performance (OR 2.570, 95% CI 1.401-4.716).
UNASSIGNED: These results suggest that malnutrition contributes to sarcopenia/severe sarcopenia in MHD patients by reducing muscle mass and strength, and physical performance.
UNASSIGNED: Nutritional status was assessed using a nutritional risk index (NRI) developed for patients undergoing MHD. This retrospective cross-sectional study included 315 MHD patients (199 males, 116 females), who were divided into low-risk (score 0-7) and medium-/high-risk (score 8-13) groups. Sarcopenia and severe sarcopenia, along with low muscle mass, low muscle strength, and low physical performance were defined using the Asian Working Group for Sarcopenia 2019 criteria.
UNASSIGNED: The median NRI score was 5.0, while the prevalence of medium-/high-risk cases among the patients was 31.1%. Additionally, the rates of those with low muscle mass, low muscle strength, and low physical performance were 55.9, 60.6, and 31.4%, respectively, while those of sarcopenia and severe sarcopenia were 44.1 and 20.0%, respectively. Multivariable logistic regression analyses revealed a significant (P < 0.001) association of NRI score with sarcopenia [odds ratio (OR) 1.255, 95% confidence interval (CI) 1.143-1.377] and severe sarcopenia (OR 1.257, 95% CI 1.122-1.407), as well as low muscle mass (OR 1.260, 95% CI 1.157-1.374), low muscle strength (OR 1.310, 95% CI 1.178-1.457), and low physical performance (OR 1.216, 95% CI 1.104-1.339). Furthermore, medium-/high-risk status showed a significant (P < 0.05) association with sarcopenia (OR 2.960, 95% CI 1.623-5.401) and severe sarcopenia (OR 2.241, 95% CI 1.151-4.362), as well as low muscle mass (OR 2.141, 95% CI 1.219-3.760), low muscle strength (OR 7.665, 95% CI 3.438-17.091), and low physical performance (OR 2.570, 95% CI 1.401-4.716).
UNASSIGNED: These results suggest that malnutrition contributes to sarcopenia/severe sarcopenia in MHD patients by reducing muscle mass and strength, and physical performance.
摘要：
■在进行维持性血液透析（MHD）的患者中经常观察到营养不良和肌肉减少症。为了阐明在这些情况下营养不良是否与肌肉减少症有关，研究了营养状况与肌肉减少症的关系。
使用为接受MHD的患者制定的营养风险指数（NRI）评估营养状况。这项回顾性横断面研究包括315名MHD患者(199名男性，116名女性），将其分为低风险（0-7分）和中/高风险（8-13分）组。少肌症和重度少肌症,伴随着低肌肉质量，肌肉力量低,和低体能表现使用亚洲工作组2019年肌肉减少症标准定义。
■NRI评分中位数为5.0，而患者中/高危病例的患病率为31.1％。此外,那些肌肉质量低的人的比率，肌肉力量低,低物理性能分别为55.9、60.6和31.4%，分别,而肌肉减少症和严重肌肉减少症分别为44.1％和20.0％，分别。多变量逻辑回归分析显示，NRI评分与肌肉减少症[比值比（OR）1.255，95％置信区间（CI）1.143-1.377]和严重肌肉减少症（OR1.257，95％CI1.122-1.407）之间存在显着关联（P<0.001）。以及低肌肉质量(OR1.260，95%CI1.157-1.374)，低肌肉力量（OR1.310，95%CI1.178-1.457），和低物理性能（OR1.216，95%CI1.104-1.339）。此外，中/高危状态显示与肌肉减少症（OR2.960，95％CI1.523-5.401）和严重肌肉减少症（OR2.241，95％CI1.151-4.362）存在显着相关性（P<0.05），以及低肌肉质量(OR2.141，95%CI1.219-3.760)，低肌肉力量（OR7.665，95%CI3.438-17.091），和低物理性能（OR2.570，95%CI1.401-4.716）。
■这些结果表明，营养不良通过减少肌肉质量和力量而导致MHD患者的肌肉减少/严重肌肉减少，和物理性能。
使用为接受MHD的患者制定的营养风险指数（NRI）评估营养状况。这项回顾性横断面研究包括315名MHD患者(199名男性，116名女性），将其分为低风险（0-7分）和中/高风险（8-13分）组。少肌症和重度少肌症,伴随着低肌肉质量，肌肉力量低,和低体能表现使用亚洲工作组2019年肌肉减少症标准定义。
■NRI评分中位数为5.0，而患者中/高危病例的患病率为31.1％。此外,那些肌肉质量低的人的比率，肌肉力量低,低物理性能分别为55.9、60.6和31.4%，分别,而肌肉减少症和严重肌肉减少症分别为44.1％和20.0％，分别。多变量逻辑回归分析显示，NRI评分与肌肉减少症[比值比（OR）1.255，95％置信区间（CI）1.143-1.377]和严重肌肉减少症（OR1.257，95％CI1.122-1.407）之间存在显着关联（P<0.001）。以及低肌肉质量(OR1.260，95%CI1.157-1.374)，低肌肉力量（OR1.310，95%CI1.178-1.457），和低物理性能（OR1.216，95%CI1.104-1.339）。此外，中/高危状态显示与肌肉减少症（OR2.960，95％CI1.523-5.401）和严重肌肉减少症（OR2.241，95％CI1.151-4.362）存在显着相关性（P<0.05），以及低肌肉质量(OR2.141，95%CI1.219-3.760)，低肌肉力量（OR7.665，95%CI3.438-17.091），和低物理性能（OR2.570，95%CI1.401-4.716）。
■这些结果表明，营养不良通过减少肌肉质量和力量而导致MHD患者的肌肉减少/严重肌肉减少，和物理性能。
