Abstract：
BACKGROUND: This study aims to investigate potential markers of psoriasis and aging, and to elucidate possible connections between these two processes.
METHODS: The serum samples of 60 psoriatic patients and 100 controls were analysed, and the levels of four selected parameters (AGEs, RAGE, NAD, and elastin) were determined using commercial ELISA kits. Serum C-reactive protein was assayed using an immune-nephelometry method.
RESULTS: Among the patients, the levels of CRP, AGEs, and RAGE were all increased, while the levels of NAD were reduced when compared to the control group. A negative correlation between the levels of AGEs and NAD was found. A negative correlation between age and the NAD levels among the control group was observed, however among the patients the relationship was diminished. While there was no difference in the levels of native elastin between the patients and the controls, a positive correlation between the levels of native elastin and age and a negative correlation between the levels of native elastin and the severity of psoriasis were found.
CONCLUSIONS: The results of our study support the notion of psoriasis and possibly other immune-mediated diseases accelerating the aging process through sustained systemic damage. The serum levels of CRP, NAD, AGEs, and RAGE appear to be promising potential biomarkers of psoriasis. The decrease in the serum levels of NAD is associated with (pro)inflammatory states. Our analysis indicates that the levels of native elastin might strongly reflect both the severity of psoriasis and the aging process.
METHODS: The serum samples of 60 psoriatic patients and 100 controls were analysed, and the levels of four selected parameters (AGEs, RAGE, NAD, and elastin) were determined using commercial ELISA kits. Serum C-reactive protein was assayed using an immune-nephelometry method.
RESULTS: Among the patients, the levels of CRP, AGEs, and RAGE were all increased, while the levels of NAD were reduced when compared to the control group. A negative correlation between the levels of AGEs and NAD was found. A negative correlation between age and the NAD levels among the control group was observed, however among the patients the relationship was diminished. While there was no difference in the levels of native elastin between the patients and the controls, a positive correlation between the levels of native elastin and age and a negative correlation between the levels of native elastin and the severity of psoriasis were found.
CONCLUSIONS: The results of our study support the notion of psoriasis and possibly other immune-mediated diseases accelerating the aging process through sustained systemic damage. The serum levels of CRP, NAD, AGEs, and RAGE appear to be promising potential biomarkers of psoriasis. The decrease in the serum levels of NAD is associated with (pro)inflammatory states. Our analysis indicates that the levels of native elastin might strongly reflect both the severity of psoriasis and the aging process.
摘要：
背景：这项研究旨在调查牛皮癣和衰老的潜在标志物，并阐明这两个过程之间可能的联系。
方法：分析了60例银屑病患者和100例对照的血清样本，以及四个选定参数的级别(AGEs，愤怒,NAD,和弹性蛋白）使用商业ELISA试剂盒确定。使用免疫比浊法测定血清C反应蛋白。
结果：在患者中，CRP的水平，AGEs,愤怒都增加了，与对照组相比，NAD水平降低。AGEs与NAD水平呈负相关。对照组的NAD水平与年龄呈负相关,然而，在患者中，这种关系被削弱了。虽然患者和对照组之间的天然弹性蛋白水平没有差异，发现天然弹性蛋白水平与年龄呈正相关，天然弹性蛋白水平与银屑病严重程度呈负相关。
结论：我们的研究结果支持银屑病和其他可能的免疫介导的疾病通过持续的全身损伤加速衰老过程的概念。血清CRP水平,NAD,AGEs,和RAGE似乎是有希望的潜在的银屑病生物标志物。NAD的血清水平的降低与(促炎)状态相关。我们的分析表明，天然弹性蛋白的水平可能强烈反映牛皮癣的严重程度和衰老过程。
方法：分析了60例银屑病患者和100例对照的血清样本，以及四个选定参数的级别(AGEs，愤怒,NAD,和弹性蛋白）使用商业ELISA试剂盒确定。使用免疫比浊法测定血清C反应蛋白。
结果：在患者中，CRP的水平，AGEs,愤怒都增加了，与对照组相比，NAD水平降低。AGEs与NAD水平呈负相关。对照组的NAD水平与年龄呈负相关,然而，在患者中，这种关系被削弱了。虽然患者和对照组之间的天然弹性蛋白水平没有差异，发现天然弹性蛋白水平与年龄呈正相关，天然弹性蛋白水平与银屑病严重程度呈负相关。
结论：我们的研究结果支持银屑病和其他可能的免疫介导的疾病通过持续的全身损伤加速衰老过程的概念。血清CRP水平,NAD,AGEs,和RAGE似乎是有希望的潜在的银屑病生物标志物。NAD的血清水平的降低与(促炎)状态相关。我们的分析表明，天然弹性蛋白的水平可能强烈反映牛皮癣的严重程度和衰老过程。
