Abstract：
Ecto-5\'-nucleotidase (CD73), the ectoenzyme that together with CD39 is responsible for extracellular ATP hydrolysis and adenosine accumulation, regulates immune/inflammatory processes by controlling innate and acquired immunity cell functions. We previously demonstrated that CD73 is required for the assessment of a controlled allergic sensitization, in mice. Here, we evaluated the response to aerosolized allergen of female-sensitized mice lacking CD73 in comparison with their wild type counterpart. Results obtained show, in mice lacking CD73, the absence of airway hyperreactivity in response to an allergen challenge, paralleled by reduced airway CD23+B cells and IL4+T cells pulmonary accumulation together with reduced mast cells accumulation and degranulation. Our findings indicate CD73 as a potential therapeutic target for allergic asthma.
摘要：
ECto-5'-核苷酸酶（CD73），与CD39一起负责细胞外ATP水解和腺苷积累的胞外酶，通过控制先天和获得性免疫细胞功能来调节免疫/炎症过程。我们先前证明CD73是评估受控变态反应致敏所必需的，在老鼠身上。这里,我们评估了缺乏CD73的雌性致敏小鼠与野生型小鼠对雾化过敏原的反应。获得的结果表明，在缺乏CD73的小鼠中，缺乏对过敏原攻击的气道高反应性，同时气道CD23+B细胞和IL4+T细胞肺积累减少，肥大细胞积累和脱颗粒减少。我们的发现表明CD73是过敏性哮喘的潜在治疗靶点。
