Abstract:
Interleukin (IL)-10 family cytokines include IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, and IL-29. These cytokines play crucial regulatory roles in various biological reactions and diseases. In recent years, several studies have shown that the IL-10 family plays a vital role in bone and joint diseases, including bone metabolic diseases, fractures, osteoarthritis, rheumatoid arthritis, and bone tumors. Herein, the recent progress on the regulatory role of IL-10 family of cytokines in the occurrence and development of bone and joint diseases has been summarized. This review will provide novel directions for immunotherapy of bone and joint diseases.
摘要:
白细胞介素(IL)-10家族细胞因子包括IL-10、IL-19、IL-20、IL-22、IL-24、IL-26、IL-28A、IL-28B,IL-29这些细胞因子在各种生物反应和疾病中起着至关重要的调节作用。近年来,多项研究表明,IL-10家族在骨关节疾病中起着至关重要的作用,包括骨代谢疾病,骨折,骨关节炎,类风湿性关节炎,和骨肿瘤。在这里,综述了细胞因子IL-10家族在骨关节疾病发生发展中的调控作用的最新进展。本综述将为骨关节疾病的免疫治疗提供新的方向。