Abstract：
Interleukin (IL)-10 family cytokines include IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, and IL-29. These cytokines play crucial regulatory roles in various biological reactions and diseases. In recent years, several studies have shown that the IL-10 family plays a vital role in bone and joint diseases, including bone metabolic diseases, fractures, osteoarthritis, rheumatoid arthritis, and bone tumors. Herein, the recent progress on the regulatory role of IL-10 family of cytokines in the occurrence and development of bone and joint diseases has been summarized. This review will provide novel directions for immunotherapy of bone and joint diseases.
摘要：
白细胞介素(IL)-10家族细胞因子包括IL-10、IL-19、IL-20、IL-22、IL-24、IL-26、IL-28A、IL-28B,IL-29这些细胞因子在各种生物反应和疾病中起着至关重要的调节作用。近年来,多项研究表明，IL-10家族在骨关节疾病中起着至关重要的作用，包括骨代谢疾病，骨折,骨关节炎,类风湿性关节炎,和骨肿瘤。在这里，综述了细胞因子IL-10家族在骨关节疾病发生发展中的调控作用的最新进展。本综述将为骨关节疾病的免疫治疗提供新的方向。
