PDF(Pubmed)
Abstract：
UNASSIGNED: COVID-19 is characterized by endothelial dysfunction and is presumed to have long-term cardiovascular sequelae. In this cross-sectional study, we aimed to explore the serum levels of endothelial biomarkers in patients who recovered from COVID-19 one year after hospital discharge.
UNASSIGNED: In this clinical follow-up study, 345 COVID-19 survivors from Huanggang, Hubei, and 119 age and gender-matched medical staff as healthy controls were enrolled. A standardized symptom questionnaire was performed, while electrocardiogram and Doppler ultrasound of lower extremities, routine blood tests, biochemical and immunological tests, serum soluble vascular cell adhesion molecule-1(VCAM-1), intercellular cell adhesion molecule-1(ICAM-1), P-selectin, and fractalkine were measured by enzyme-linked immunosorbent assays (ELISA).
UNASSIGNED: At one year after discharge, 39% of recovers possessed post-COVID syndromes, while a few had abnormal electrocardiogram manifestations, and no deep vein thrombosis was detected in all screened survivors. There were no significant differences in circulatory inflammatory markers (leukocytes, neutrophils, lymphocytes, C-reactive protein and interleukin-6), alanine aminotransferase, estimated glomerular filtration rate, glucose, triglycerides, total cholesterol and D-dimer observed among healthy controls with previously mild or severe infected. Furthermore, serum levels of VCAM-1, ICAM-1, P-selectin, and fractalkine do not significantly differ between survivors and healthy controls.
UNASSIGNED: SARS-CoV-2 infection may not impose a higher risk of developing long-term cardiovascular events, even for those recovering from severe illness.
UNASSIGNED: In this clinical follow-up study, 345 COVID-19 survivors from Huanggang, Hubei, and 119 age and gender-matched medical staff as healthy controls were enrolled. A standardized symptom questionnaire was performed, while electrocardiogram and Doppler ultrasound of lower extremities, routine blood tests, biochemical and immunological tests, serum soluble vascular cell adhesion molecule-1(VCAM-1), intercellular cell adhesion molecule-1(ICAM-1), P-selectin, and fractalkine were measured by enzyme-linked immunosorbent assays (ELISA).
UNASSIGNED: At one year after discharge, 39% of recovers possessed post-COVID syndromes, while a few had abnormal electrocardiogram manifestations, and no deep vein thrombosis was detected in all screened survivors. There were no significant differences in circulatory inflammatory markers (leukocytes, neutrophils, lymphocytes, C-reactive protein and interleukin-6), alanine aminotransferase, estimated glomerular filtration rate, glucose, triglycerides, total cholesterol and D-dimer observed among healthy controls with previously mild or severe infected. Furthermore, serum levels of VCAM-1, ICAM-1, P-selectin, and fractalkine do not significantly differ between survivors and healthy controls.
UNASSIGNED: SARS-CoV-2 infection may not impose a higher risk of developing long-term cardiovascular events, even for those recovering from severe illness.
摘要：
未经证实：COVID-19以内皮功能障碍为特征，推测有长期心血管后遗症。在这项横断面研究中，我们旨在探讨出院后1年从COVID-19中康复的患者的血清内皮生物标志物水平.
未经证实：在这项临床随访研究中，345名来自黄冈的COVID-19幸存者，湖北,纳入119名年龄和性别匹配的医务人员作为健康对照.进行了标准化症状问卷，而下肢的心电图和多普勒超声，血常规检查,生化和免疫学测试，血清可溶性血管细胞粘附分子-1（VCAM-1），细胞间粘附分子-1(ICAM-1),P-选择素,和fractalkine通过酶联免疫吸附测定（ELISA）进行测量。
UNASSIGNED：出院后一年，39%的康复者患有后COVID综合征，而少数有异常的心电图表现,在所有筛选的幸存者中均未发现深静脉血栓形成.循环炎症标志物(白细胞，中性粒细胞，淋巴细胞，C反应蛋白和白细胞介素-6），丙氨酸氨基转移酶，估计肾小球滤过率，葡萄糖，甘油三酯，在先前轻度或重度感染的健康对照中观察到的总胆固醇和D-二聚体。此外，血清VCAM-1，ICAM-1，P-选择素，和fractalkine在幸存者和健康对照之间没有显着差异。
未经评估：SARS-CoV-2感染可能不会增加发生长期心血管事件的风险，即使是那些从严重疾病中康复的人。
未经证实：在这项临床随访研究中，345名来自黄冈的COVID-19幸存者，湖北,纳入119名年龄和性别匹配的医务人员作为健康对照.进行了标准化症状问卷，而下肢的心电图和多普勒超声，血常规检查,生化和免疫学测试，血清可溶性血管细胞粘附分子-1（VCAM-1），细胞间粘附分子-1(ICAM-1),P-选择素,和fractalkine通过酶联免疫吸附测定（ELISA）进行测量。
UNASSIGNED：出院后一年，39%的康复者患有后COVID综合征，而少数有异常的心电图表现,在所有筛选的幸存者中均未发现深静脉血栓形成.循环炎症标志物(白细胞，中性粒细胞，淋巴细胞，C反应蛋白和白细胞介素-6），丙氨酸氨基转移酶，估计肾小球滤过率，葡萄糖，甘油三酯，在先前轻度或重度感染的健康对照中观察到的总胆固醇和D-二聚体。此外，血清VCAM-1，ICAM-1，P-选择素，和fractalkine在幸存者和健康对照之间没有显着差异。
未经评估：SARS-CoV-2感染可能不会增加发生长期心血管事件的风险，即使是那些从严重疾病中康复的人。
