{Reference Type}: Journal Article
{Title}: Endothelial Biomarkers in Patients Recovered from COVID-19 One Year after Hospital Discharge: A Cross-Sectional Study.
{Author}: Tong M;Yan X;Jiang Y;Jin Z;Zhu S;Zou L;Liu Y;Zheng Q;Chen G;Gu R;Zhou Z;Han X;He J;Yin S;Ma C;Xiao W;Zeng Y;Chen F;Zhu Y;
{Journal}: Mediterr J Hematol Infect Dis
{Volume}: 14
{Issue}: 1
{Year}: 2022
{Factor}: 3.122
{DOI}: 10.4084/MJHID.2022.033
{Abstract}: <B>UNASSIGNED: </B>COVID-19 is characterized by endothelial dysfunction and is presumed to have long-term cardiovascular sequelae. In this cross-sectional study, we aimed to explore the serum levels of endothelial biomarkers in patients who recovered from COVID-19 one year after hospital discharge.<BR><B>UNASSIGNED: </B>In this clinical follow-up study, 345 COVID-19 survivors from Huanggang, Hubei, and 119 age and gender-matched medical staff as healthy controls were enrolled. A standardized symptom questionnaire was performed, while electrocardiogram and Doppler ultrasound of lower extremities, routine blood tests, biochemical and immunological tests, serum soluble vascular cell adhesion molecule-1(VCAM-1), intercellular cell adhesion molecule-1(ICAM-1), P-selectin, and fractalkine were measured by enzyme-linked immunosorbent assays (ELISA).<BR><B>UNASSIGNED: </B>At one year after discharge, 39% of recovers possessed post-COVID syndromes, while a few had abnormal electrocardiogram manifestations, and no deep vein thrombosis was detected in all screened survivors. There were no significant differences in circulatory inflammatory markers (leukocytes, neutrophils, lymphocytes, C-reactive protein and interleukin-6), alanine aminotransferase, estimated glomerular filtration rate, glucose, triglycerides, total cholesterol and D-dimer observed among healthy controls with previously mild or severe infected. Furthermore, serum levels of VCAM-1, ICAM-1, P-selectin, and fractalkine do not significantly differ between survivors and healthy controls.<BR><B>UNASSIGNED: </B>SARS-CoV-2 infection may not impose a higher risk of developing long-term cardiovascular events, even for those recovering from severe illness.