Abstract：
BACKGROUND: Posterior internal fixation (PIF) is commonly used in the treatment of thoracolumbar fracture (TLF), but there is still no standard for the number of fixed segments. The objective of this meta-analysis was to evaluate the efficacy and safety of short segment (SS), intermediate segment (IS) and long segment (LS) in the fixation of TLF.
METHODS: Two authors independently searched through PubMed, Embase, Cochrane Library and Web of Science for studies of thoracolumbar fracture treated by posterior internal fixation, which were published until the end of April 2021. The Aggregate Data Drug Information System (ADDIS) software was used for data evaluation according to the Markov chain Monte Carlo (MCMC) method based on the Bayesian theorem.
RESULTS: Nineteen trials evaluating a total of 970 patients were enrolled in these studies, of which 340 in the SS group, 429 in the IS group and 201 in the LS group. For anterior vertebral height ratio (AVHR), IS had the highest AVHR, LS had the second highest AVHR. IS also ranked first in reducing visual analogue scale (VAS), SS ranked second. For sagittal Cobb\'s angle (SCA), LS had the lowest SCA and IS had the second lowest SCA. In terms of adverse events, IS had the lowest implant failure rate and LS had the second lowest implant failure rate.
CONCLUSIONS: IS may be the most desirable treatment option for TLF in reducing SCA, implant failure rate, VAS, and improving AVHR. However, more randomized controlled trials are needed to verify these results.
METHODS: Two authors independently searched through PubMed, Embase, Cochrane Library and Web of Science for studies of thoracolumbar fracture treated by posterior internal fixation, which were published until the end of April 2021. The Aggregate Data Drug Information System (ADDIS) software was used for data evaluation according to the Markov chain Monte Carlo (MCMC) method based on the Bayesian theorem.
RESULTS: Nineteen trials evaluating a total of 970 patients were enrolled in these studies, of which 340 in the SS group, 429 in the IS group and 201 in the LS group. For anterior vertebral height ratio (AVHR), IS had the highest AVHR, LS had the second highest AVHR. IS also ranked first in reducing visual analogue scale (VAS), SS ranked second. For sagittal Cobb\'s angle (SCA), LS had the lowest SCA and IS had the second lowest SCA. In terms of adverse events, IS had the lowest implant failure rate and LS had the second lowest implant failure rate.
CONCLUSIONS: IS may be the most desirable treatment option for TLF in reducing SCA, implant failure rate, VAS, and improving AVHR. However, more randomized controlled trials are needed to verify these results.
摘要：
背景：后路内固定（PIF）通常用于治疗胸腰椎骨折（TLF），但是固定段数仍然没有标准。这项荟萃分析的目的是评估短节段（SS）的有效性和安全性，TLF固定中的中段(IS)和长段(LS)。
方法：两位作者通过PubMed独立搜索，Embase,Cochrane图书馆和WebofScience用于后路内固定治疗胸腰椎骨折的研究，直到2021年4月底才出版。根据基于贝叶斯定理的马尔可夫链蒙特卡洛(MCMC)方法,采用综合数据药物信息系统(ADDIS)软件进行数据评价。
结果：共有19项研究纳入了970名患者，其中340个在SS组中，IS组中的429和LS组中的201。对于前椎体高度比(AVHR)，IS有最高的AVHR，LS的AVHR排名第二。IS在降低视觉模拟量表(VAS)方面也排名第一，SS排名第二。对于矢状Cobb角(SCA)，LS的SCA最低，IS的SCA第二低。在不良事件方面，IS的植入物失败率最低，LS的植入物失败率第二低。
结论：IS可能是TLF减少SCA的最理想治疗选择，植入物故障率，VAS,改善AVHR。然而,需要更多的随机对照试验来验证这些结果.
方法：两位作者通过PubMed独立搜索，Embase,Cochrane图书馆和WebofScience用于后路内固定治疗胸腰椎骨折的研究，直到2021年4月底才出版。根据基于贝叶斯定理的马尔可夫链蒙特卡洛(MCMC)方法,采用综合数据药物信息系统(ADDIS)软件进行数据评价。
结果：共有19项研究纳入了970名患者，其中340个在SS组中，IS组中的429和LS组中的201。对于前椎体高度比(AVHR)，IS有最高的AVHR，LS的AVHR排名第二。IS在降低视觉模拟量表(VAS)方面也排名第一，SS排名第二。对于矢状Cobb角(SCA)，LS的SCA最低，IS的SCA第二低。在不良事件方面，IS的植入物失败率最低，LS的植入物失败率第二低。
结论：IS可能是TLF减少SCA的最理想治疗选择，植入物故障率，VAS,改善AVHR。然而,需要更多的随机对照试验来验证这些结果.
