Abstract：
Patients with acute uncomplicated pyelonephritis often show impaired immune function that aggravates infectious diseases. Some of the therapeutic recommendations for UTIs have been revised recently, partly because of the emergence of antibiotic resistant bacteria such as quinolone-resistant Escherichia coli and Extended spectrum beta-lactamase (ESBL) producing bacteria, mainly E. coli and Klebsiella pneumoniae, which vary from country to country or between regions in frequency of emergence and spread. An era of antimicrobial resistance (AMR) has arrived, where the use of antibiotics should be reconsidered. Several newly established antimicrobial agents are commercially available for the treatment of resistant bacteria, such as penicillins or cephalosporins with beta-lactamase inhibitors. This new edition of Asian Association of UTI & STI (AAUS) guideline for acute uncomplicated pyelonephritis includes new recommendations for antibiotic use based on changing trends in antibiotic resistance.
摘要：
急性单纯性肾盂肾炎患者常表现为免疫功能受损，加重感染性疾病。最近对UTI的一些治疗建议进行了修订，部分原因是抗生素耐药菌的出现，如喹诺酮耐药大肠杆菌和产超广谱β-内酰胺酶（ESBL）的细菌，主要是大肠杆菌和肺炎克雷伯菌，不同国家或地区之间的出现和传播频率不同。抗菌素耐药性（AMR）的时代已经到来，应该重新考虑使用抗生素。几种新建立的抗微生物剂可用于治疗耐药细菌，如青霉素或头孢菌素与β-内酰胺酶抑制剂。新版的亚洲尿路感染和性传播感染协会（AAUS）急性单纯性肾盂肾炎指南包括基于抗生素耐药性变化趋势的抗生素使用新建议。
