Abstract：
OBJECTIVE: COVID-19 due to SARS-CoV-2 virus is a new cause of severe acute respiratory syndrome (SARS). Little is known about the short-term cognitive prognosis for these patients. We prospectively evaluated basic cognitive functions shortly after care in the intensive care unit (ICU) and three months later in post-ICU COVID-19 patients.
METHODS: We performed a prospective single-center study in our institution in Paris. Patients with SARS-CoV-2 SARS were prospectively recruited via our ICU. Patients were evaluated using standardized cognitive tests at baseline and at three months\' follow-up. Our primary endpoint was the evolution of the following five global tests: MMSE, FAB, oral naming test, Dubois five words test and MADRS.
RESULTS: We explored 13 patients at baseline and follow-up. All patients had cognitive impairment at baseline but they all improved at three months, significantly on two of the five global tests after Bonferroni correction for multiple testing: MMSE (median 18 (IQR [15-22]) and 27 (IQR [27-29]) respectively, P=0.002) and FAB test (median 14 (IQR [14-17]) and 17 (IQR [17,18]) respectively, P=0.002).
CONCLUSIONS: We report here the first longitudinal data on short-term cognitive impairment after intensive care in COVID-19 patients. We found acute and short-term cognitive impairment but significant improvement at three months. This pattern does not seem to differ from other causes of post-intensive care syndrome.
METHODS: We performed a prospective single-center study in our institution in Paris. Patients with SARS-CoV-2 SARS were prospectively recruited via our ICU. Patients were evaluated using standardized cognitive tests at baseline and at three months\' follow-up. Our primary endpoint was the evolution of the following five global tests: MMSE, FAB, oral naming test, Dubois five words test and MADRS.
RESULTS: We explored 13 patients at baseline and follow-up. All patients had cognitive impairment at baseline but they all improved at three months, significantly on two of the five global tests after Bonferroni correction for multiple testing: MMSE (median 18 (IQR [15-22]) and 27 (IQR [27-29]) respectively, P=0.002) and FAB test (median 14 (IQR [14-17]) and 17 (IQR [17,18]) respectively, P=0.002).
CONCLUSIONS: We report here the first longitudinal data on short-term cognitive impairment after intensive care in COVID-19 patients. We found acute and short-term cognitive impairment but significant improvement at three months. This pattern does not seem to differ from other causes of post-intensive care syndrome.
摘要：
目的：由SARS-CoV-2病毒引起的COVID-19是严重急性呼吸道综合征（SARS）的新病因。对这些患者的短期认知预后知之甚少。我们前瞻性评估了重症监护病房（ICU）护理后不久和3个月后ICU后COVID-19患者的基本认知功能。
方法：我们在巴黎的机构进行了一项前瞻性单中心研究。SARS-CoV-2SARS患者是通过我们的ICU前瞻性招募的。在基线和随访三个月时使用标准化认知测试对患者进行评估。我们的主要终点是以下五项全球测试的演变：MMSE，FAB,口头命名测试，Dubois五个单词测试和MADRS。
结果：我们在基线和随访时调查了13例患者。所有患者在基线时都有认知障碍，但在三个月时都有所改善，在Bonferroni校正多重测试后的五项全球测试中，有两项显着：MMSE（中位数分别为18（IQR[15-22]）和27（IQR[27-29]），P=0.002）和FAB测试（中位数分别为14（IQR[14-17]）和17（IQR[17,18]），P=0.002)。
结论：我们在此报告COVID-19患者重症监护后短期认知障碍的第一个纵向数据。我们发现急性和短期认知障碍，但在三个月时有显着改善。这种模式似乎与重症监护后综合征的其他原因没有区别。
方法：我们在巴黎的机构进行了一项前瞻性单中心研究。SARS-CoV-2SARS患者是通过我们的ICU前瞻性招募的。在基线和随访三个月时使用标准化认知测试对患者进行评估。我们的主要终点是以下五项全球测试的演变：MMSE，FAB,口头命名测试，Dubois五个单词测试和MADRS。
结果：我们在基线和随访时调查了13例患者。所有患者在基线时都有认知障碍，但在三个月时都有所改善，在Bonferroni校正多重测试后的五项全球测试中，有两项显着：MMSE（中位数分别为18（IQR[15-22]）和27（IQR[27-29]），P=0.002）和FAB测试（中位数分别为14（IQR[14-17]）和17（IQR[17,18]），P=0.002)。
结论：我们在此报告COVID-19患者重症监护后短期认知障碍的第一个纵向数据。我们发现急性和短期认知障碍，但在三个月时有显着改善。这种模式似乎与重症监护后综合征的其他原因没有区别。
