PDF(Pubmed)
Abstract：
Disease activity and severity of eosinophilic esophagitis (EoE) dictate therapeutic options and management, but the decision-making process for determining severity varies among practitioners. To reduce variability in practice patterns and help clinicians monitor the clinical course of the disease in an office setting, we aimed to create an international consensus severity scoring index for EoE.
A multidisciplinary international group of adult and pediatric EoE researchers and clinicians, as well as non-EoE allergy immunology and gastroenterology experts, formed 3 teams to review the existing literature on histology, endoscopy, and symptoms of EoE in the context of progression and severity. A steering committee convened a 1-day virtual meeting to reach consensus on each team\'s opinion on salient features of severity across key clinicopathologic domains and distill features that would allow providers to categorize disease severity.
Symptom features and complications and inflammatory and fibrostenotic features on both endoscopic and histologic examination were collated into a simplified scoring system-the Index of Severity for Eosinophilic Esophagitis (I-SEE)-that can be completed at routine clinic visits to assess disease severity using a point scale of 0-6 for mild, 7-14 for moderate, and ≥15 for severe EoE.
A multidisciplinary team of experts iteratively created a clinically usable EoE severity scoring system denominated \"I-SEE\" to guide practitioners in EoE management by standardizing disease components reflecting disease severity beyond eosinophil counts. I-SEE should be validated and refined using data from future clinical trials and routine clinical practice to increase its utilization and functionality.
A multidisciplinary international group of adult and pediatric EoE researchers and clinicians, as well as non-EoE allergy immunology and gastroenterology experts, formed 3 teams to review the existing literature on histology, endoscopy, and symptoms of EoE in the context of progression and severity. A steering committee convened a 1-day virtual meeting to reach consensus on each team\'s opinion on salient features of severity across key clinicopathologic domains and distill features that would allow providers to categorize disease severity.
Symptom features and complications and inflammatory and fibrostenotic features on both endoscopic and histologic examination were collated into a simplified scoring system-the Index of Severity for Eosinophilic Esophagitis (I-SEE)-that can be completed at routine clinic visits to assess disease severity using a point scale of 0-6 for mild, 7-14 for moderate, and ≥15 for severe EoE.
A multidisciplinary team of experts iteratively created a clinically usable EoE severity scoring system denominated \"I-SEE\" to guide practitioners in EoE management by standardizing disease components reflecting disease severity beyond eosinophil counts. I-SEE should be validated and refined using data from future clinical trials and routine clinical practice to increase its utilization and functionality.
摘要：
嗜酸细胞性食管炎（EoE）的疾病活动性和严重程度决定了治疗方案和管理，但是确定严重程度的决策过程因从业人员而异。为了减少实践模式的可变性，并帮助临床医生在办公室环境中监测疾病的临床过程，我们的目标是为EoE创建一个国际共识的严重程度评分指数。
由成人和儿科EoE研究人员和临床医生组成的多学科国际小组，以及非EoE过敏免疫学和胃肠病学专家，组成了3个小组来回顾现有的组织学文献，内窥镜检查,以及EoE在进展和严重程度方面的症状。指导委员会召开了为期1天的虚拟会议，就每个团队对关键临床病理领域严重程度的显着特征的意见达成共识，并提炼出允许提供者对疾病严重程度进行分类的特征。
内窥镜和组织学检查的症状特征和并发症以及炎症和纤维狭窄特征被整理为简化的评分系统-嗜酸性食管炎严重程度指数（I-SEE）-可以在常规临床就诊时完成，以评估轻度疾病的严重程度。7-14为中度，重度EoE≥15。
一个多学科专家团队反复创建了一个临床可用的EoE严重程度评分系统，命名为“I-SEE”，通过标准化反映嗜酸性粒细胞计数以外的疾病严重程度的疾病成分，指导从业人员进行EoE管理。I-SEE应使用来自未来临床试验和常规临床实践的数据进行验证和完善，以提高其利用率和功能。
由成人和儿科EoE研究人员和临床医生组成的多学科国际小组，以及非EoE过敏免疫学和胃肠病学专家，组成了3个小组来回顾现有的组织学文献，内窥镜检查,以及EoE在进展和严重程度方面的症状。指导委员会召开了为期1天的虚拟会议，就每个团队对关键临床病理领域严重程度的显着特征的意见达成共识，并提炼出允许提供者对疾病严重程度进行分类的特征。
内窥镜和组织学检查的症状特征和并发症以及炎症和纤维狭窄特征被整理为简化的评分系统-嗜酸性食管炎严重程度指数（I-SEE）-可以在常规临床就诊时完成，以评估轻度疾病的严重程度。7-14为中度，重度EoE≥15。
一个多学科专家团队反复创建了一个临床可用的EoE严重程度评分系统，命名为“I-SEE”，通过标准化反映嗜酸性粒细胞计数以外的疾病严重程度的疾病成分，指导从业人员进行EoE管理。I-SEE应使用来自未来临床试验和常规临床实践的数据进行验证和完善，以提高其利用率和功能。
