PDF(Pubmed)
Abstract：
UNASSIGNED: To investigate the distribution characteristics of gut microbiota in children with tic disorder (TD) and the possible role of these characteristics in the pathogenesis of TD.
UNASSIGNED: The medical records of 28 children with TD treated at Wuxi Children\'s Hospital from January 1 to October 31, 2020, and 21 age-matched healthy children (controls) were included. The relative quantification of bacterial taxa was performed using 16S ribosomal RNA gene amplicon sequencing.
UNASSIGNED: There was no significant difference in the alpha diversity of gut microbiota between the TD and control groups. Analyses of beta diversity were able to differentiate the TD patients from the healthy controls based on their gut microbiota. At the phylum level, the two groups were mainly composed of four phyla, Firmicutes, Actinobacteria, Bacteroidetes, and Proteobacteria. There were significant differences in Firmicutes and Actinobacteria between the two groups (P <0.05). At the level of genera, the abundance of Bifidobacterium and Collinsella reduced while that of Ruminococcaceae unclassified, Prevotella, Faecalibacterium, Coprobacillus, and Odoribacter increased in the TD group compared to that in the control group. The intergroup differences were significant (P < 0.05).
UNASSIGNED: The abnormal composition of gut microbiota in children with TD suggests that the change in gut microbiota may play an important role in TD development.
UNASSIGNED: The medical records of 28 children with TD treated at Wuxi Children\'s Hospital from January 1 to October 31, 2020, and 21 age-matched healthy children (controls) were included. The relative quantification of bacterial taxa was performed using 16S ribosomal RNA gene amplicon sequencing.
UNASSIGNED: There was no significant difference in the alpha diversity of gut microbiota between the TD and control groups. Analyses of beta diversity were able to differentiate the TD patients from the healthy controls based on their gut microbiota. At the phylum level, the two groups were mainly composed of four phyla, Firmicutes, Actinobacteria, Bacteroidetes, and Proteobacteria. There were significant differences in Firmicutes and Actinobacteria between the two groups (P <0.05). At the level of genera, the abundance of Bifidobacterium and Collinsella reduced while that of Ruminococcaceae unclassified, Prevotella, Faecalibacterium, Coprobacillus, and Odoribacter increased in the TD group compared to that in the control group. The intergroup differences were significant (P < 0.05).
UNASSIGNED: The abnormal composition of gut microbiota in children with TD suggests that the change in gut microbiota may play an important role in TD development.
摘要：
未经证实：探讨抽动障碍（TD）患儿肠道菌群的分布特征及其在TD发病机制中的可能作用。
UNASSIGNED：纳入了2020年1月1日至10月31日在无锡市儿童医院治疗的28名TD患儿和21名年龄匹配的健康儿童（对照）的病历。使用16S核糖体RNA基因扩增子测序进行细菌分类群的相对定量。
UNASSIGNED：TD组和对照组之间的肠道微生物群的α多样性没有显着差异。β多样性分析能够根据肠道微生物群将TD患者与健康对照区分开来。在门一级，两组主要由四个门组成，Firmicutes,放线菌,拟杆菌,和变形杆菌。两组的Firmicutes和放线菌差异有统计学意义（P<0.05）。在属一级，双歧杆菌和Collinsella的丰度减少，而Ruminococcaceae未分类，普雷沃氏菌,粪杆菌,Copropacillus,与对照组相比，TD组的Odoribacter增加。组间差异有统计学意义(P<0.05)。
UNASSIGNED：TD患儿肠道菌群的异常组成表明，肠道菌群的变化可能在TD发育中起重要作用。
UNASSIGNED：纳入了2020年1月1日至10月31日在无锡市儿童医院治疗的28名TD患儿和21名年龄匹配的健康儿童（对照）的病历。使用16S核糖体RNA基因扩增子测序进行细菌分类群的相对定量。
UNASSIGNED：TD组和对照组之间的肠道微生物群的α多样性没有显着差异。β多样性分析能够根据肠道微生物群将TD患者与健康对照区分开来。在门一级，两组主要由四个门组成，Firmicutes,放线菌,拟杆菌,和变形杆菌。两组的Firmicutes和放线菌差异有统计学意义（P<0.05）。在属一级，双歧杆菌和Collinsella的丰度减少，而Ruminococcaceae未分类，普雷沃氏菌,粪杆菌,Copropacillus,与对照组相比，TD组的Odoribacter增加。组间差异有统计学意义(P<0.05)。
UNASSIGNED：TD患儿肠道菌群的异常组成表明，肠道菌群的变化可能在TD发育中起重要作用。
